A1 Journal article (refereed)
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring (2019)


Wiklund, Petri; Karhunen, Ville; Richmond, Rebecca C.; Parmar, Priyanka; Rodriguez, Alina; De Silva, Maneka; Wielscher, Matthias; Rezwan, Faisal I.; Richardson, Tom G.; Veijola, Juha et al. (2019). DNA methylation links prenatal smoking exposure to later life health outcomes in offspring. Clinical Epigenetics, 11, 97. DOI: 10.1186/s13148-019-0683-4


JYU authors or editors


Publication details

All authors or editors: Wiklund, Petri; Karhunen, Ville; Richmond, Rebecca C.; Parmar, Priyanka; Rodriguez, Alina; De Silva, Maneka; Wielscher, Matthias; Rezwan, Faisal I.; Richardson, Tom G.; Veijola, Juha; et al.
Journal or series: Clinical Epigenetics
ISSN: 1868-7075
eISSN: 1868-7083
Publication year: 2019
Volume: 11
Article number: 97
Publisher: Biomed Central
Publication country: United Kingdom
Publication language: English
Open Access: Publication published in an open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/65110


Abstract

Background: Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship.
Methods: We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring.
Results: We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes.
Conclusions: DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.

Free keywords: causality; DNA methylation; disease; life course; maternal smoking; mediation; persistence; pregnancy


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Ministry reporting: Yes
Preliminary JUFO rating: 1

Last updated on 2019-25-07 at 08:40