Olli Pentikäinen
ORCID-linkki: http://orcid.org/0000-0001-7188-4016
Ei aktiivista nimitystä
Tutkimuskuvaus
Tutkimuksemme keskittyy uusien tehokkaiden lääkeaineiden etsimiseen sekä siihen liittyvien uusien menetelmien kehitykseen. Erityisesti aiemmin mahdottomina pidetyt syöpälääkekehityskohteet yhdessä lääkeaineiden riskiarvioinnin kanssa muodostavat tällä hetkellä tutkimuksemme pääpainoalueet.
Hankkeet, joissa vastuullinen johtaja
- Pienmolekyylipainoisten Lääkeaineiden kehityksen Uudelleen Suuntaaminen (toinen käyttöulottuvuus)
- TEKES
Julkaisut
1/3
- A Practical Perspective : The Effect of Ligand Conformers on the Negative Image-Based Screening (2019) Ahinko, Mira; et al.; A1; OA
- Development of New Coumarin-Based Profluorescent Substrates for Human Cytochrome P450 Enzymes (2019) Juvonen, Risto O.; et al.; A1; OA
- Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors (2019) Jokinen, Elmeri M.; et al.; A1; OA
- Suitability of MMGBSA for the selection of correct ligand binding modes from docking results (2019) Ahinko, Mira; et al.; A1; OA
- Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018) Niinivehmas, Sanna; et al.; A1; OA
- Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening (2018) Rauhamäki, Sanna; et al.; A1; OA
- Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana (2018) Hopkins, David; et al.; A1; OA
- Improving Docking Performance Using Negative Image-Based Rescoring (2018) Kurkinen, Sami; et al.; A1; OA
- Molecular docking-based design and development of a highly selective probe substrate for UDP-glucuronosyltransferase 1A10 (2018) Juvonen, Risto O.; et al.; A1; OA
- Structure-Activity Relationship Analysis of 3-phenylcoumarin-Based Monoamine Oxidase B Inhibitors (2018) Rauhamäki, Sanna; et al.; A1; OA
- Identification of the privileged position in the imidazo[1,2-a]pyridine ring of phosphonocarboxylates for development of Rab geranylgeranyl transferase (RGGT) inhibitors (2017) Kaźmierczak, Aleksandra; et al.; A1; OA
- Skeletal Dysplasia Mutations Effect on Human Filamins’ Structure and Mechanosensing (2017) Seppälä, Jonne; et al.; A1; OA
- Identification of estrogen receptor α ligands with virtual screening techniques (2016) Niinivehmas, Sanna; et al.; A1; OA
- Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes (2016) Juvonen, Risto O.; et al.; A1
- Rocker : Open source, easy-to-use tool for AUC and enrichment calculations and ROC visualization (2016) Lätti, Sakari; et al.; A1; OA
- Temperature-dependent mutational robustness can explain faster molecular evolution at warm temperatures, affecting speciation rate and global patterns of species diversity (2016) Puurtinen, Mikael; et al.; A1; OA
- The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes (2016) Yasuda, Tomokazu; et al.; A1
- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015) Virtanen, Salla; et al.; A1
- Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015) Raunio, Hannu; et al.; A2; OA
- Reliability of Virtual Screening Methods in Prediction of PDE4Binhibitor Activity (2015) Shubina, Victoria; et al.; A1
