Juhani Huuskonen

Aktiiviset JYU-affiliaatiot

Tutkimuskuvaus

Tutkimuksesta: Teen yhteistyöprojektina bioaktiivisten (mahdollisten lääkeaineena toimivien) molekyylien synteesisuunnittelua ja synteesiä. Toinen tutkimusalue on taideteosten materiaalitutkimus ja menetelmien kehitystä yhteistyönä Recenart Oy:n kanssa.

Tieteenalat

Seurantakohteet

Julkaisut ja muut tuotokset

  

  

  

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• Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13 (2021) Juvonen, Risto O.; et al.; A1; OA 
• Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes : In Vitro Enzyme Kinetics and In Silico Modeling (2021) Juvonen, Risto O.; et al.; A1; OA 
• In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs (2020) Juvonen, Risto O.; et al.; A1; OA
• In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species (2020) Juvonen, Risto O.; et al.; A1; OA
• Development of New Coumarin-Based Profluorescent Substrates for Human Cytochrome P450 Enzymes (2019) Juvonen, Risto O.; et al.; A1; OA
• Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018) Niinivehmas, Sanna; et al.; A1; OA 
• Molecular docking-based design and development of a highly selective probe substrate for UDP-glucuronosyltransferase 1A10 (2018) Juvonen, Risto O.; et al.; A1; OA 
• Identification of estrogen receptor α ligands with virtual screening techniques (2016) Niinivehmas, Sanna; et al.; A1; OA 
• Synthesis and Topological Determination of Hexakis-Substituted 1,4- Ditritylbenzene and Nonakis-Substituted 1,3,5-Tritritylbenzene Derivatives: Building Blocks for Higher Supramolecular Assemblies (2013) Plietzsch, O.; et al.; A1 
• A Novel MALDI-MS Approach for the Analysis of Neutral Metallosupramolecular Architectures (2012) Même, Aurélie; et al.; A1 
• Chelate Cooperativity and Spacer Length Effects on the Assembly Thermodynamics and Kinetics of Divalent Pseudorotaxanes (2012) Jiang, Wei; et al.; A1 
• Self-ordering of metallogrid complexes via directed hydrogen-bonding (2012) Stefankiewicz, Artur R.; et al.; A1 
• Substituent effects on axle binding in amide pseudorotaxanes: comparison of NMR titration and ITC data with DFT calculations (2012) Kaufmann, Lena; et al.; A1 
• Blockage of Collagen Binding to Integrin alpha2beta1: Structure-activity Relationship of Protein-protein Interaction Inhibitors (2011) Koivunen, Jarkko; et al.; A1; OA
• Discriminating octahedral transition metal ions: Highly selective tripodal tris-(2,2 ́-bipyridine) functionalized piperazine cyclophane receptor for Cu2+ ions (2011) Raatikainen, Kari; et al.; A1