Perttu Permi
Henkilökunnan yhteystiedot saatavilla yliopiston yhteystietohausta.
ORCID-linkki: http://orcid.org/0000-0002-6281-1138
Aktiiviset JYU-affiliaatiot
- Bio- ja ympäristötieteiden laitos, Professori
Tutkimuskuvaus
Tutkimme proteiinin rakenteen ja toiminnan välistä yhteyttä biofysikaalisten tutkimusmenetelmien, erityisesti NMR-spektroskopian avulla. Tutkimuskohteena ovat mm. solujen viestiliikennettä ohjaavat proteiinit, joihin erilaiset taudinaiheuttajat pyrkivät vaikuttamaan yrittäessään kaapata monimutkaisen koneiston hallintaansa.
Hankkeet, joissa vastuullinen johtaja
- COVID19 infektiota estämään kalpaiini-inhibiittoreilla
- Suomen Akatemia
- Laskostumattomien proteiinien konformationaalisten ominaisuuksien tutkiminen biofysikaalisin menetelmin
- Suomen Akatemia
- Peptidoglyg. vastaan resistentti Staphylococcus aureus
- Jane ja Aatos Erkon säätiö
- Peptidoglykaanihydrolaasit vastaan antibioottiresistentti Staphylococcus aureus
- Suomen Akatemia
Julkaisut
1/2
- 1H, 13C, and 15N NMR chemical shift assignment of the complex formed by the first EPEC EspF repeat and N-WASP GTPase binding domain (2021) Karjalainen, Mikael; et al.; A1; OA
- The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor (2021) Eesmaa, Ave; et al.; A1; OA
- 1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16) (2020) Thapa, Chandan J.; et al.; A1; OA
- Dispersion from Cα or NH : 4D experiments for backbone resonance assignment of intrinsically disordered proteins (2020) Tossavainen, Helena; et al.; A1; OA
- HACANCOi : a new Hα-detected experiment for backbone resonance assignment of intrinsically disordered proteins (2020) Karjalainen, Mikael; et al.; A1; OA
- Alternative biosynthetic starter units enhance the structural diversity of cyanobacterial lipopeptides (2019) Mareš, Jan; et al.; A1; OA
- Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors (2019) Shapiguzov, Alexey; et al.; A1; OA
- Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes (2019) Humisto, Anu; et al.; A1; OA
- Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia (2019) Haataja, Tatu J.K.; et al.; A1; OA
- Towards Controlled Synthesis of Water-Soluble Gold Nanoclusters : Synthesis and Analysis (2019) Sokolowska, Karolina; et al.; A1; OA
- Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium (2018) Kust, Andreja; et al.; A1; OA
- Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease (2018) Kaukonen, Maria; et al.; A1; OA
- Structural and Functional Insights into Lysostaphin-Substrate Interaction (2018) Tossavainen, Helena; et al.; A1; OA
- The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450 (2018) Humisto, Anu; et al.; A1; OA
- 1H, 13C and 15N NMR chemical shift assignments of A. thaliana RCD1 RST (2017) Tossavainen, Helena; et al.; A1
- 1H, 13C and 15N resonance assignments of the new lysostaphin family endopeptidase catalytic domain from Staphylococcus aureus (2017) Raulinaitis, Vytas; et al.; A1
- A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8 (2017) Ahlstrand, Tuuli; et al.; A1; OA
- Characterization of sulfhydryl oxidase from Aspergillus tubingensis (2017) Nivala, Outi; et al.; A1; OA
- Dynamic Stabilization of the Ligand-Metal Interface in Atomically Precise Gold Nanoclusters Au68 and Au144 Protected by meta-Mercaptobenzoic Acid (2017) Tero, Tiia-Riikka; et al.; A1; OA
- Fine-tuning the extent and dynamics of binding cleft opening as a potential general regulatory mechanism in parvulin-type peptidyl prolyl isomerases (2017) Czajlik, András; et al.; A1; OA
