Vasculature as a central mediator of the health benefits of exercise in aging and cardiometabolic diseases (VascExe)
Main funder
Funder's project number: 348636
Funds granted by main funder (€)
- 499 499,00
Funding program
Project timetable
Project start date: 01/09/2022
Project end date: 31/08/2026
Summary
This study aims for identification of clinically relevant mechanisms of the health effects of exercise/physical activity in cardiometabolic disease (CMD) patients. This will be achieved by combining data from clinical studies of CMD patients, who have been assigned to exercise medicine clinic (EMClinic) and mechanistic studies using animal disease models and cell culture experiments mimicking exercise. Our experimental set-up features a multi-omics approach that will allow us to decipher cell-specific responses to exercise in various tissues and to identify metabolic mediators of inter-tissue crosstalk in the blood. The overarching aim of this study is to advance our understanding of the mechanisms mediating the health benefits of exercise among the individuals who have the largest need for it, and to discover and test novel therapeutic targets for CMD.