Indole-based ligand toolbox (INBAT)

Main funder

Funder's project number: 346895

Funds granted by main funder (€)

Funding program

Project timetable

Project start date: 01/09/2022

Project end date: 31/08/2025

Summary

This work will rely on the application of indole derivatives as the outcome-controlling π-bound ligands in a number of purposefully designed palladium-catalyzed CDC transformations of β-ketoesters. In the course of this work, we will uncover the mechanistic details of indole’s participation in these catalytic processes, keeping particular emphasis on its individual and cooperative role in controlling the stereochemistry during the β-ketoester functionalization. These comprehensive studies on indole’s involvement in transition metal catalysis will strongly benefit the scientific community by uncovering a new ligand space that can be further exploited in a variety of synthetic applications.

Principal Investigator

Other persons related to this project (JYU)

Primary responsible unit