Lomittunut tertiäärirakenne (ProteoKnot)


Rahoittajan antama koodi/diaarinumero: 101088884

Päärahoittajan myöntämä tuki (€)

  • 1 999 454,00


Hankkeen aikataulu

Hankkeen aloituspäivämäärä: 01.06.2023

Hankkeen päättymispäivämäärä: 31.05.2028


The most sophisticated functions of proteins emerge at the level of their tertiary structure and involve large amplitude conformational changes. In contrast, the functions of synthetic molecules are currently limited by our inability to control their structure beyond the level of static secondary structures. ProteoKnot seeks to address this limitation by introducing entanglements as a tool to control tertiary folding while maintaining the flexibility required to allow them to change conformation. The first objective of this project is to establish design principles to guide the construction of entangled tertiary folds. These principles will be tested with the assembly of multiply-stranded helices (WP1), entangled macromolecules (WP2) and polymers (WP3). The second objective is to introduce photoswitchable handles to enable remote control over their conformational states (WP4). Operating the transition from the traditional design of static secondary folds to the design of dynamic tertiary folds will unlock the possibility to engineer increasingly complex macromolecules with protein-like functions. These exquisite architectures feature tandem helical motifs and cavities, providing an avenue toward highly elaborated receptors and catalysts. To illustrate the great potential of entangled tertiary folds for future applications, our third objective will be to develop their use as multi-responsive switchable catalysts (WP5).

Vastuullinen johtaja

Muut hankkeeseen liittyvät henkilöt (JYU)

Päävastuullinen yksikkö

Sisäinen seurantakohde

Profiloitumisalue: Nanoscience Center (Fysiikan laitos PHYS, JYFL) (Matemaattis-luonnontieteellinen tiedekunta) (Kemian laitos CHEM) (Bio- ja ympäristötieteiden laitos BIOENV) NSC

Viimeisin päivitys 2023-04-05 klo 06:32