Halogen(I) Chemistry: Reactivity, Supramolecules, and Nanoreactors ( HI:ReS Nano)

Main funder

Funder's project number: 356187

Funds granted by main funder (€)

Funding program

Project timetable

Project start date: 01/09/2023

Project end date: 31/08/2027

Summary

The Halogen(I): Reactivity, Supramolecules, and Nanoreactors (HI:ReS Nano) project aims to open up completely new areas of research in the field of halogen bonding and halogen(I) complexes (halogen elements in the exotic +1 oxidation state). The proposed HI:ReS Nano project will pursue several highly innovative objectives including the first examples of chiral and asymmetric halogen(I) reagents based on hypoiodites, new multi-functional halogen(I) materials based on hierarchical design principles, and the development of environmentally-friendly processes (e.g., mechanochemistry) and techniques (e.g., solid-state NMR spectroscopy) for the synthesis, study, and application of halogen(I) species. These synthetic targets and applications of halogen(I) ions are all highly innovative and currently unprecedented, and though they are completely original, are rooted in established knowledge in the field to maximise their chances of success. The objectives will be achieved by utilising a myriad of modern analytical techniques, including NMR spectroscopy (1D, 2D, heteronuclear, and solid-state), infra-red spectroscopy (IR), ultraviolet–visible spectroscopy (UV-Vis), gas chromatography (GC), elemental analysis (EA), thermogravimetric analysis (TGA), powder X-ray crystallography (PXRD), and single crystal X-ray crystallography (SCXRD). As is the nature of all exploratory research, the study of the unprecedented reactivity of these newly described species has the potential to bring about fresh discoveries for more efficient chemical transformations and reactions. The envisioned chiral and asymmetric hypoiodite iodine(I) species would offer unique reagents, potentially capable of synthesising enantiopure halogenated molecules when reacted with olefins, which are invaluable target compounds and synthetic intermediates for the pharmaceutical, agrochemical, fragrance, and flavour industries. The pioneering of ‘green’, mechanochemical production methods for the synthesis and use of iodine(I) reagents is cutting-edge research, and will drastically shift conventional wisdom in areas like organic chemistry and drug design, with immense benefits expected for the development and production of medicinal compounds. These objectives are completely new chemistry, and if successful, would all be breakthroughs in the field of halogen(I) chemistry, with the outcomes of the HI:ReS Nano research project having far-reaching implications for the academic, scientific, and industrial sectors.

Principal Investigator

Primary responsible unit

Fields of science

Follow-up groups

Profiling area: Nanoscience Center (Department of Physics PHYS, JYFL) (Faculty of Mathematics and Science) (Department of Chemistry CHEM) (Department of Biological and Environmental Science BIOENV) NSC

Related publications and other outputs