Towards personalized exercise: Identifying the determinants of individual variation in resistance training, detraining, and retraining (TraDeRe)
Main funder
Funder's project number: 357185
Funds granted by main funder (€)
- 533 321,00
Funding program
Project timetable
Project start date: 01/09/2023
Project end date: 31/08/2027
Summary
It is well established that regular resistance exercise training (RT) can induce health benefits. However, remarkably heterogeneity is observed in responses to RT. The mechanisms underlying heterogeneity in the individual’s ability to respond to RT are largely unknown but it will include a complex network of genomic and non-genomic determinants. Moreover, an intra-individual variation on RT outcomes in trial-to-trial study design is not known although that information is crucial to understand individual responsiveness to RT.
We aim to examine heterogeneity in physiological responses to RT while other environmental contributors are closely monitored (e.g. physical activity levels, nutrition, sleep, and stress). The participants are healthy sedentary 20-35 years old men and women (n=150) randomized to intervention (RT) and control (non-training) arms. To characterize RT responsiveness, the RT group participate to the supervised 12-week RT intervention followed by a 20-week detraining period. Thereafter, the 12-week RT is repeated to establish the within-subject variability of the RT outcomes. Controls continue their normal daily physical activities with no RT.
The research material is collected before, during, and after the study periods by utilizing the state-of-the-art measures of body composition, physical fitness characteristics, and protein synthesis rate, as well as collecting blood and muscle samples and questionnaires.
We will identify and examine biological networks to elucidate why people differ in their physiological responses to RT. As a novel approach, investigation of the integrative personal OMIC profiling by metabolomics, transcriptomics, and genomics are combined not only with RT outcomes but also their physiological determinants as well as with the other potential modulators of RT responses. This way we aim to find common denominators that underpin individual differences in responsiveness to RT. Sophisticated analyzing methods are utilized to reveal new predictors of training responsiveness for different traits.
The overall aim of this research project is to gain knowledge of the sources of individual variability in the physiological responses to RT. On that basis, exercise-training can be personalized so that the benefits of RT could be optimized for all individuals. Eventually, we can also better justify RT as a part of personalized health care strategies in the future.
We aim to examine heterogeneity in physiological responses to RT while other environmental contributors are closely monitored (e.g. physical activity levels, nutrition, sleep, and stress). The participants are healthy sedentary 20-35 years old men and women (n=150) randomized to intervention (RT) and control (non-training) arms. To characterize RT responsiveness, the RT group participate to the supervised 12-week RT intervention followed by a 20-week detraining period. Thereafter, the 12-week RT is repeated to establish the within-subject variability of the RT outcomes. Controls continue their normal daily physical activities with no RT.
The research material is collected before, during, and after the study periods by utilizing the state-of-the-art measures of body composition, physical fitness characteristics, and protein synthesis rate, as well as collecting blood and muscle samples and questionnaires.
We will identify and examine biological networks to elucidate why people differ in their physiological responses to RT. As a novel approach, investigation of the integrative personal OMIC profiling by metabolomics, transcriptomics, and genomics are combined not only with RT outcomes but also their physiological determinants as well as with the other potential modulators of RT responses. This way we aim to find common denominators that underpin individual differences in responsiveness to RT. Sophisticated analyzing methods are utilized to reveal new predictors of training responsiveness for different traits.
The overall aim of this research project is to gain knowledge of the sources of individual variability in the physiological responses to RT. On that basis, exercise-training can be personalized so that the benefits of RT could be optimized for all individuals. Eventually, we can also better justify RT as a part of personalized health care strategies in the future.
Principal Investigator
Other persons related to this project (JYU)
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS; School of Wellbeing (University of Jyväskylä JYU) JYU.Well
Related publications and other outputs
- Effects of Acute Loading Induced Fatigability, Acute Serum Hormone Responses and Training Volume to Individual Hypertrophy and Maximal Strength during 10 Weeks of Strength Training (2023) Räntilä, Aapo; et al.; A1; OA
- Inter‐individual variation in responses to resistance training in cardiometabolic health indicators (2020) Ahtiainen, Juha P.; et al.; A1; OA
- Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training (2018) Ahtiainen, Juha; et al.; A1; OA
- Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages (2016) Ahtiainen, Juha; et al.; A1
