Exercise, Extracellular vesicles and Senescence (EEVaS)
Molecular mechanisms promoting healthspan (EEVaS)
Main funder
Funder's project number: 354603
Funds granted by main funder (€)
- 702 781,00
Funding program
Project timetable
Project start date: 01/09/2023
Project end date: 31/08/2027
Summary
Age is the main risk factor for the prevalent chronic diseases of developed countries. This fact has raised the question whether we should treat aging instead of treating individual diseases. Accumulation of senescent cells with age underlie several chronic diseases, whereas exercise diminishes the markers of cellular senescence. The biological significance of cellular senescence on healthy aging remains yet to be fully understood. Exercise, Extracellular vesicles and Senescence - Molecular mechanisms promoting healthspan (EEVaS) study aims to establish the key signaling molecules mediating the senolytic effects of exercise. To reveal the mechanisms, EEVaS study utilizes cell, animal, and human models. The study will be carried out at the Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland. When successful, the results of EEVaS study have potential to be translational to human health in delaying the onset of age-related chronic diseases and hence, increasing healthspan.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Behaviour change, health, and well-being across the lifespan (University of Jyväskylä JYU) BC-Well; School of Wellbeing (University of Jyväskylä JYU) JYU.Well