Investigating causal interactions between physical activity and cardiometabolic disease via polygenic risk scores (GenActive) (GenActive)
Main funder
Funder's project number: 361981
Funds granted by main funder (€)
- 199 997,00
Funding program
Project timetable
Project start date: 01/05/2024
Project end date: 31/08/2026
Summary
Human behaviour and disease progression are affected by environmental factors, genetic inheritance and their complex interplay. Genetic contributions to complex traits and diseases, such as PA and cardiometabolic disease (CMD), are polygenic. Novel polygenic risk scores summarise genome-wide genotype data into single variables that produce individual-level risk scores for genetic liability. This study seeks to research causal associations between genetic inheritance, physical activity and CMD by utilising large population based datasets (FinnGen, HUNT), genetically controlled longitudinal follow-up data on twins (Finnish twin cohort), polygenic scores and advance statistical methods. Further, I aim to use DNA methylation data to identify potential mechanisms and pathways that regulate associations between genetic risk and CMD and mortality and validate these findings with gene expression analysis and metabolomics.
Principal Investigator
Other persons related to this project (JYU)
Primary responsible unit
Follow-up groups
- Behaviour change, health, and well-being across the lifespan (University of Jyväskylä JYU) BC-Well
- Gerontology and Public Health (Faculty of Sport and Health Sciences LTK, SPORT) TGE
- Physical activity through life span (University of Jyväskylä JYU) PACTS
- School of Wellbeing (University of Jyväskylä JYU) JYU.Well