Fight the resistance – Peptidoglycan hydrolases as weapons against resistant Staphylococcus aureus


Main funder

Funder's project number: 323435


Funds granted by main funder (€)

  • 599 820,00


Funding program


Project timetable

Project start date: 01/09/2019

Project end date: 31/08/2023


Summary

Staphylococcus aureus is a bacterium of great concern because of its high virulence and ability to cause life-threatening infections. S. aureus is increasingly resistant to a greater number of antibiotics; MRSA strains can be concomitantly resistant to many groups of antibiotics and alarmingly, also to the drugs of last resort. Resistance severely complicates treatment, increases mortality and greatly raises the costs of treatment. Need for novel drugs against resistant S. aureus is pressing. We study enzymes that degrade S. aureus cell wall by cleaving glycyl-glycine bonds. Specificity and lytic potency makes these enzymes attractive targets of drug development. Using several biophysical techniques we characterize the enzyme–cell wall interaction at atomic scale and tackle enzyme regulation. Solving the structure–function relation enables enzyme engineering to a high-potency drug and development of tools to interfere with regulation as alternative means to exploit them as antibiotics.


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Last updated on 2021-17-03 at 12:09