Optimizing learning - synchrony of the brain and body as a tool?
Main funder
Funder's project number: 321522
Funds granted by main funder (€)
- 475 904,00
Funding program
Project timetable
Project start date: 01/09/2019
Project end date: 31/08/2023
Summary
Oscillatory brain activity regulates complex cognition and is coupled with rhythmic bodily functions, such as the cardiac cycle and breathing. However, it is unclear how this synchrony regulates the basic processes of neural plasticity. Further, there are few studies where knowledge on the synchrony between bodily rhythms and brain oscillations would have been utilized to modify learning. Here we first aim to find out how synaptic modification in the brain is regulated by the brain-body synchrony. Next, we will study if and how we can enhance learning by optimizing training based on online monitoring of bodily rhythms known to synchronize with brain oscillations in 1) healthy adult humans, 2) in an animal model of memory impairment, and at last 3) in a group of patients suffering from memory disorders. The idea is to find out if even in a degenerated brain there is still momentary potential for plasticity that can be captured with noninvasive measures of bodily rhythms.
Principal Investigator
Other persons related to this project (JYU)
Primary responsible unit
Web page
https://www.jyu.fi/fi/tutkimusryhmat/oppimisen-ja-muistin-hermostollinen-perusta
Fields of science
Follow-up groups
Profiling area: Behaviour change, health, and well-being across the lifespan (University of Jyväskylä JYU) BC-Well; School of Wellbeing (University of Jyväskylä JYU) JYU.Well
Related publications and other outputs
- Cardiorespiratory rhythm -contingent trace eyeblink conditioning in elderly adults (2024) Santhana Gopalan, Praghajieeth Raajhen; et al.; A1
- Intrinsic running capacity associates with hippocampal electrophysiology and long-term potentiation in rats (2024) Mäkinen, Elina E.; et al.; A1; OA
- CA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats (2023) Nokia, Miriam S.; et al.; A1; OA
- Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats (2023) Mäkinen, Elina; et al.; A1; OA
- Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease (2023) Driuchina, Anastasiia; et al.; A1; OA
- Uni ja muisti (2023) Kurkela, Jari L.; et al.; A2; OA
- Cardiac cycle and respiration phase affect responses to the conditioned stimulus in young adults trained in trace eyeblink conditioning (2022) Waselius, Tomi; et al.; A1; OA
- Cardiorespiratory rhythms, brain oscillatory activity and cognition : review of evidence and proposal for significance (2022) Parviainen, Tiina; et al.; A2
- Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes (2022) Lehtonen, Suvi‐Maaria; et al.; A1; OA
- Red Light Optogenetics in Neuroscience (2022) Lehtinen, Kimmo; et al.; A2; OA
