Way out through chromatin: nuclear exit of herpesvirus mRNA and capsids
Main funder
Funder's project number: 330896
Funds granted by main funder (€)
- 548 195,00
Funding program
Project timetable
Project start date: 01/09/2020
Project end date: 31/08/2024
Summary
The understanding of intranuclear herpesvirus dynamics is essential for basic research and for the development of oncolytic virus therapy and novel antivirals that aim to block the viral life cycle. The general goal of this project is to unravel the mechanisms of virus-induced chromatin reorganization. The specific objectives are to determine the mechanisms of virus protein-induced alterations of the chromatin architecture, and to study the dynamics of viral mRNA and capsids within the chromatin network. Our research utilizes a new interdisciplinary approach combining biology and biophysics with cutting-edge techniques of imaging, advanced image analysis, and biophysical modeling.
Principal Investigator
Primary responsible unit
Related publications and other outputs
- Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses (2024) Ojha, Ravi; et al.; A1; OA
- Herpesvirus-Induced Manipulation of the Nucleolus (2024) Leclerc, Simon; et al.; O1; OA
- Creation of ordered 3D tubes out of DNA origami lattices (2023) Parikka, Johannes M.; et al.; A1; OA
- Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina (2023) Mäntylä, Elina; et al.; A1; OA
- Mitochondrial Reorganization in Herpesvirus-Infected Cells (2023) Leclerc, S.; et al.; O1; OA
- G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids (2022) Mattola, Salla; et al.; A1; OA
- Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium (2022) Fadjukov, Julia; et al.; A1; OA
- Nuclear entry and egress of parvoviruses (2022) Mattola, Salla; et al.; A2; OA
- Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins (2022) Mattola, Salla; et al.; A1; OA
- Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells (2022) Chen, Jian-Hua; et al.; A1; OA
