Way out through chromatin: nuclear exit of herpesvirus mRNA and capsids
Main funder
Funder's project number: 330896
Funds granted by main funder (€)
- 548 195,00
Funding program
Project timetable
Project start date: 01/09/2020
Project end date: 31/08/2024
Summary
The understanding of intranuclear herpesvirus dynamics is essential for basic research and for the development of oncolytic virus therapy and novel antivirals that aim to block the viral life cycle. The general goal of this project is to unravel the mechanisms of virus-induced chromatin reorganization. The specific objectives are to determine the mechanisms of virus protein-induced alterations of the chromatin architecture, and to study the dynamics of viral mRNA and capsids within the chromatin network. Our research utilizes a new interdisciplinary approach combining biology and biophysics with cutting-edge techniques of imaging, advanced image analysis, and biophysical modeling.
Principal Investigator
Primary responsible unit
Related publications and other outputs
- Concepts to Reveal Parvovirus–Nucleus Interactions (2021) Mattola, Salla; et al.; A2; OA
- Functional roles of the membrane-associated AAV protein MAAP (2021) Galibert, Lionel; et al.; A1; OA
- Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane (2021) Aho, Vesa; et al.; A1; OA
- Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection (2021) Xu, Man; et al.; A1; OA
