Way out through chromatin: nuclear exit of herpesvirus mRNA and capsids


Main funder


Funds granted by main funder (€)

548 195,00


Funding program

Academy Project, AoF (Academy of Finland)


Project timetable

Project start date: 01/09/2020

Project end date: 31/08/2024


Summary

The understanding of intranuclear herpesvirus dynamics is essential for basic research and for the development of oncolytic virus therapy and novel antivirals that aim to block the viral life cycle. The general goal of this project is to unravel the mechanisms of virus-induced chromatin reorganization. The specific objectives are to determine the mechanisms of virus protein-induced alterations of the chromatin architecture, and to study the dynamics of viral mRNA and capsids within the chromatin network. Our research utilizes a new interdisciplinary approach combining biology and biophysics with cutting-edge techniques of imaging, advanced image analysis, and biophysical modeling.


Principal Investigator


Primary responsible unit


Last updated on 2020-05-08 at 12:29