Possiblities of biological disease management in aquaculture


Main funder

Funder's project number: 304615


Funds granted by main funder (€)

  • 297 316,00


Funding program


Project timetable

Project start date: 01/10/2016

Project end date: 30/09/2018


Summary

Aquaculture production is a steadily growing food production industry, but hampered by a variety of diseases. This project aims to characterize lytic enzymes derived from bacteriophages, the viruses that infect only bacteria, to specifically degrade the fish pathogen Flavobacterium columnare from the fish farming environment. The lytic enzymes naturally hydrolyse bacterial cell wall during the phage infection cycle, and they have been demonstrated as efficient anti-infectives against several human pathogens. I will use experimental evolution to increase infectivity of the F. columnare phages. Potential lytic genes are identified using whole genome sequencing. Candidate lytic enzymes will be produced in E. coli, and their efficiency will be tested against the target pathogen cultures and in disinfection of bacterial biofilm grown in fish rearing tanks at a fish farm.


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Last updated on 2021-17-03 at 12:04