Filamiinien fysiologisten ominaisuuksien
Main funder
Funder's project number: 283481
Funds granted by main funder (€)
- 430 750,00
Funding program
Project timetable
Project start date: 01/09/2014
Project end date: 31/08/2017
Summary
The regulation of the cellular functions is complicated and important process. One way how cells perform this task is converting of mechanical forces into biochemical. Filamins are one of the most important molecules which transmit the mechanical force induced biochemical signals in cells. Structurally filamins are large proteins that bind simultaneously to actin filaments and transmembrane receptors, such as integrins. Mutations in filamin genes can be either lethal or to lead brain, bone, heart and cardiovascular developmental disorders. The aim of this research, done in the Department of Biological and Environmental Sciences at University of Jyväskylä, is to find out how the mutations in filamin genes effect on filamin’s structure and function. In addition, mechanical force induced changes in filamins structure and function will be investigated. Various structural biology and computational biophysics methods will be used.
Principal Investigator
Primary responsible unit
Internal follow-up group
Related publications and other outputs
- Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A (2022) Thapa, Chandan; et al.; A1; OA
- The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A (2021) Thapa, Chandan; et al.; A1; OA
- Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia (2019) Haataja, Tatu J.K.; et al.; A1; OA
- Skeletal Dysplasia Mutations Effect on Human Filamins’ Structure and Mechanosensing (2017) Seppälä, Jonne; et al.; A1; OA
