Risk of metabolic dysfunction in middle aged women: physical activity and systemic and intracrine estrogen and microRNAs as mediating factors (EsmiRs)
Main funder
Funder's project number: 309504
Funds granted by main funder (€)
- 434 485,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/08/2022
Summary
Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 3-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, miR-omics) and data integrated to the repeated measures of physical activity (self-reported and objective accelometric measurements), sex steroid hormones, and traditional metabolic disorder risk factors. The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects the entire female body and health, and that its biological factors can be, if needed, manipulated.
Principal Investigator
Primary responsible unit
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