Risk of metabolic dysfunction in middle aged women: physical activity and systemic and intracrine estrogen and microRNAs as mediating factors (EsmiRs)


Main funder

Funder's project number: 309504


Funds granted by main funder (€)

  • 434 485,00


Funding program


Project timetable

Project start date: 01/09/2017

Project end date: 31/08/2022


Summary

Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 3-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, miR-omics) and data integrated to the repeated measures of physical activity (self-reported and objective accelometric measurements), sex steroid hormones, and traditional metabolic disorder risk factors. The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects the entire female body and health, and that its biological factors can be, if needed, manipulated.


Principal Investigator


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Last updated on 2021-12-04 at 15:07