Risk of metabolic dysfunction in middle aged women: physical activity and systemic and intracrine estrogen and microRNAs as mediating factors (EsmiRs)
Main funder
Funder's project number: 309504
Funds granted by main funder (€)
- 434 485,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/08/2022
Summary
Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 3-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, miR-omics) and data integrated to the repeated measures of physical activity (self-reported and objective accelometric measurements), sex steroid hormones, and traditional metabolic disorder risk factors. The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects the entire female body and health, and that its biological factors can be, if needed, manipulated.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS
Related publications and other outputs
- Menopausal transition alters female skeletal muscle transcriptome (2024) Juppi, Hanna-Kaarina; et al.; A1; OA
- Physical activity, menopausal symptoms, and cardiometabolic health during the menopausal transition (2024) Hyvärinen, Matti; G5; OA; 978-951-39-9953-7
- The role of cardiorespiratory fitness and body composition in the association between physical activity and menopausal symptoms (2024) Hyvärinen, Matti; et al.; A1; OA
- Age but not menopausal status is linked to lower resting energy expenditure (2023) Karppinen, Jari E.; et al.; A1; OA
- Associations of the menopausal transition with body composition : examining the influence of hormonal changes, muscle RNA signaling and lifestyle habits (2023) Juppi, Hanna-Kaarina; G5; OA; 978-951-39-9615-4
- Early adulthood and current physical activity and their association with symptoms of pelvic floor disorders in middle-aged women : an observational study with retrospective physical activity assessment (2023) Kuutti, Mari A.; et al.; A1; OA
- Extracellular vesicles and high‐density lipoproteins : Exercise and oestrogen‐responsive small RNA carriers (2023) Karvinen, Sira; et al.; A1; OA
- Menopausal symptoms and cardiometabolic risk factors in middle-aged women : A cross-sectional and longitudinal study with 4-year follow-up (2023) Hyvärinen, Matti; et al.; A1; OA
- Menopause, physical activity, and whole-body metabolism with an emphasis on resting energy expenditure, fat oxidation, and serum metabolome (2023) Karppinen, Jari; G5; OA; 978-951-39-9575-1
- Associations of cardiorespiratory fitness, body composition, and blood pressure with arterial stiffness in adolescent, young adult, and middle-aged women (2022) Haapala, Eero A.; et al.; A1; OA
