Risk of metabolic dysfunction in middle aged women: physical activity and systemic and intracrine estrogen and microRNAs as mediating factors (EsmiRs)
Main funder
Funder's project number: 309504
Funds granted by main funder (€)
- 434 485,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/08/2022
Summary
Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 3-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, miR-omics) and data integrated to the repeated measures of physical activity (self-reported and objective accelometric measurements), sex steroid hormones, and traditional metabolic disorder risk factors. The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects the entire female body and health, and that its biological factors can be, if needed, manipulated.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS
Related publications and other outputs
- Bidirectional associations between cognitive functions and walking performance among middle-aged women (2022) Tirkkonen, Anna; et al.; A1; OA
- Menopause modulates the circulating metabolome : evidence from a prospective cohort study (2022) Karppinen, Jari E.; et al.; A1; OA
- Metabolic health, menopause, and physical activity : a 4-year follow-up study (2022) Hyvärinen, Matti; et al.; A1; OA
- Personality, motivational, and social cognition predictors of leisure-time physical activity (2022) Kekäläinen, Tiia; et al.; A1; OA
- Total and regional body adiposity increases during menopause : evidence from a follow‐up study (2022) Juppi, Hanna‐Kaarina; et al.; A1; OA
- Associations of physical performance and physical activity with mental well-being in middle-aged women (2021) Bondarev, Dmitriy; et al.; A1; OA
- Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause (2021) Laakkonen, Eija K.; et al.; A1; OA
- Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning (2021) Sillanpää, Elina; et al.; A1; OA
- Estradiol deficiency and skeletal muscle apoptosis : Possible contribution of microRNAs (2021) Karvinen, Sira; et al.; A1; OA
- Perimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms (2021) Pesonen, Heidi; et al.; A1; OA
