Risk of metabolic dysfunction in middle aged women: systemic and intracrine oestrogen and microRNAs as mediating factors (EsmiRs) (EsmiRs)


Main funder


Funds granted by main funder (€)

330 000,00


Funding program

Research costs of Academy Research Fellow, AoF (Academy of Finland)


Project timetable

Project start date: 01/09/2017

Project end date: 31/08/2020


Summary

Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 4-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, NGS) and data integrated to the repeated measures of sex steroid hormones, traditional and new metabolic disorder risk factors, and physical activity (self-reported & objective accelerometer measures). The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects entire female body and health.


Principal Investigator


Primary responsible unit


Related publications


Last updated on 2020-15-10 at 12:42