Risk of metabolic dysfunction in middle aged women: systemic and intracrine oestrogen and microRNAs as mediating factors (EsmiRs) (EsmiRs)
Main funder
Funder's project number: 314181
Funds granted by main funder (€)
- 330 000,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/08/2020
Summary
Menopause with hormonal transition is significant life-event, which may have dramatic effects on women's health thereafter. This project determines the specific regulatory functions of systemic and intramuscular estradiol in microRNA-mediated regulation of tissue interactions as contributing factors to the risk of metabolic dysfunction in aging women. Study utilizes animal and cell models as well as longitudinal study on middle-aged women with new 4-year follow-up. The collected biospecimens will be analyzed with methods of genome-wide molecular biology (proteomics, NGS) and data integrated to the repeated measures of sex steroid hormones, traditional and new metabolic disorder risk factors, and physical activity (self-reported & objective accelerometer measures). The holistic approach of this study will produce urgently needed knowledge of menopausal transition as a process that affects entire female body and health.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS
Related publications and other outputs
- Accelerometer-measured and self-reported physical activity in relation to extraversion and neuroticism : a cross-sectional analysis of two studies (2020) Kekäläinen, Tiia; et al.; A1; OA
- Adolescent Sport Participation and Age at Menarche in Relation to Midlife Body Composition, Bone Mineral Density, Fitness, and Physical Activity (2020) Ravi, Suvi; et al.; A1; OA
- Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women (2020) Juppi, Hanna-Kaarina; et al.; A1; OA
- Validity and Reliability of a Single Question for Leisure-Time Physical Activity Assessment in Middle-Aged Women (2020) Hyvärinen, Matti; et al.; A1; OA
- Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women : cross-sectional and longitudinal evidence (2019) Karvinen, Sira; et al.; A1; OA
