Hippocampal oscillations and associative learning: Stepping out of the maze and
exploring new waves (research costs)
Main funder
Funder's project number: 313334
Funds granted by main funder (€)
- 6 160,00
Funding program
Project timetable
Project start date: 01/09/2017
Project end date: 31/12/2019
Summary
Hippocampus is undoubtedly the brain structure most involved in learning and memory. Yet, research has been focused on only a limited set of phenomena: It is currently hypothesized that hippocampal oscillations called theta (~6 Hz) are responsible for encoding information whereas ripples (~200 Hz) are the means of long-term memory consolidation. However, evidence is limited and contradictory. Here, the role of both hippocampal theta and ripples in learning are investigated using a model of associative learning called eyeblink classical conditioning. In addition, the role of hippocampal dentate spikes, a phenomenon overlooked for the past 15 years, is examined. The aim is to identify moments in time when the brain most efficiently encodes information as well as to elucidate the systems level mechanisms of memory consolidation. Eventually, the results obtained can be tested in humans and ultimately applied
to optimize learning in both healthy and diseased brains.
to optimize learning in both healthy and diseased brains.
Principal Investigator
Primary responsible unit
Follow-up groups
Profiling area: Multidisciplinary research on learning and teaching (University of Jyväskylä JYU) MultiLeTe; School of Wellbeing (University of Jyväskylä JYU) JYU.Well
Related publications and other outputs
- An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo (2021) Sanchez-Aguilera, Alberto; et al.; A1; OA
- Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats (2021) Lensu, Sanna; et al.; A1; OA
