Investigating causal interactions between physical activity and cardiometabolic disease via polygenic risk scores (GenActive)
Main funder
Funder's project number: 341750
Funds granted by main funder (€)
- 447 650,00
Funding program
Project timetable
Project start date: 01/09/2021
Project end date: 31/08/2026
Summary
Human behaviour and disease progression are affected by environmental factors, genetic inheritance and their complex interplay. Genetic contributions to complex traits and diseases, such as PA and cardiometabolic disease (CMD), are polygenic. Novel polygenic risk scores summarise genome-wide genotype data into single variables that produce individual-level risk scores for genetic liability. This study seeks to research causal associations between genetic inheritance, physical activity and CMD by utilising large population based datasets, genetically controlled longitudinal follow-up data on twins, polygenic scores and advance statistical methods. Further, I aim to use DNA methylation data to identify potential mechanisms and pathways that regulate associations between genetic risk and CMD and mortality and validate these findings with gene expression analysis and metabolomics. An analysis of twin pairs that are discordant for CMD will be conducted to minimise methodological bias.
Principal Investigator
Other persons related to this project (JYU)
Primary responsible unit
Follow-up groups
Profiling area: Physical activity through life span (University of Jyväskylä JYU) PACTS
Related publications and other outputs
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality : Findings from the Finnish Twin Cohort (2024) Joensuu, Laura; et al.; A1; OA
- Genetic Regulation of Physical Fitness in Children : A Twin Study of 15 Tests from Eurofit and Fitnessgram Test Batteries (2024) Silventoinen, Karri; et al.; A1
- Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan : A Prospective Cohort Study (2024) Herranen, Päivi; et al.; A1; OA
- Metabolic syndrome and epigenetic aging : a twin study (2024) Föhr, Tiina; et al.; A1; OA
- Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases : the HUNT study (2023) Tynkkynen, Niko Paavo; et al.; A1; OA
- Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period (2023) Föhr, Tiina; et al.; A1; OA
- Systemic circulating microRNA landscape in Lynch syndrome (2023) Sievänen, Tero; et al.; A1; OA
- A Polygenic Risk Score for Hand Grip Strength Predicts Muscle Strength and Proximal and Distal Functional Outcomes among Older Women (2022) Herranen, Päivi; et al.; A1; OA
- The role of adolescent lifestyle habits in biological aging : A prospective twin study (2022) Kankaanpää, Anna; et al.; A1; OA
