CRISPR and antagonistic coevolution with bacterial viruses – linking molecular evolution of both host and its parasite


Main funder


Funds granted by main funder (€)

515 568,00


Funding program

Academy Project, AoF (Academy of Finland)


Project timetable

Project start date: 01/09/2018

Project end date: 31/08/2022


Summary

Despite much excitement regarding the applied aspects of CRISPR, there remain numerous unresolved questions regarding 1) diversity and dynamics of CRISPR adaptation, 2) possible trade-offs between CRISPR mediated immunity and other bacterial life-history traits, 3) respective genetic adaptation in antagonistic coevolution between viruses and bacteria. I will use a phage-bacterium system to explore the functionality and diversity of host adaptive immunity both at molecular and phenotypic levels. I will also study the coevolutionary effects on the virus targeted by the bacterial immunity. This project will fill a gap in knowledge concerning overlapping coevolution of hosts and pathogens, especially outside laboratory conditions and provide central information in developing virus-based applications to tackle diseases at the current post-antibiotic era.


Principal Investigator


Primary responsible unit


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Last updated on 2019-20-08 at 11:01