Dentate gyrus - the gateway to memory? (DSpike)
Main funder
Funder's project number: 316966
Funds granted by main funder (€)
- 480 000,00
Funding program
Project timetable
Project start date: 01/09/2018
Project end date: 31/08/2022
Summary
The formation and storage of new memories of the daily events is important for our personality, functionality and social interactions. Memory formation is thought to be governed by the hippocampus together with the neocortex. Deficiencies in this memory system lead to progressive decline in the quality of everyday life. It is known that the output areas of the hippocampal system have a critical role in the storage of new memories and neocortical areas are important for cognition and emotions overall. Less is known of how the saturation of the neuronal network connections is prevented. That is, there should be a mechanism by which the efficiency of functional synaptic connections could be reduced so that they remain plastic for new experiences. We propose that a very short event of intense cellular activation of the input part of the hippocampus occurring during sleep, the dentate spike (DS), could be the basis of this mechanism. In addition, while new neurons are born in the hippocampus also in adults, we propose that new neurons would have a critical role in the formation of DSs. To test this hypothesis, normal rats and rats in which newborn neurons have been removed will perform learning tasks and DSs will be recorded. Furthermore, functional connectivity between hippocampus and cortex will be determined in those groups with functional magnetic resonance imaging and DS recording. Also, the efficiency of hippocampal synaptic connections will be increased experimentally with optogenetic and neurophysiological techniques and the role of DSs in their reduction will be determined. Finally, the large-scale interactions of the neurons activated during DSs will be determined with optical imaging. The experiments would reveal a potentially new mechanism for retaining the plasticity of the hippocampal system throughout our life.
Principal Investigator
Other persons related to this project (JYU)
Contact person (yes/no): Yes |
Primary responsible unit
Internal follow-up group
Related publications and other outputs
- CA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats (2023) Nokia, Miriam S.; et al.; A1; OA
- Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats (2023) Mäkinen, Elina; et al.; A1; OA
- Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease (2023) Driuchina, Anastasiia; et al.; A1; OA
- Uni ja muisti (2023) Kurkela, Jari L.; et al.; A2; OA
- Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes (2022) Lehtonen, Suvi‐Maaria; et al.; A1; OA
- Rhythmic Memory Consolidation in the Hippocampus (2022) Nokia, Miriam S.; et al.; A2; OA
- Gut Microbiota, Microbial Metabolites and Human Physical Performance (2021) Lensu, Sanna; et al.; A2; OA
- Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats (2021) Lensu, Sanna; et al.; A1; OA
- Suoliston mikrobit ja fyysinen suorituskyky (2021) Lensu, Sanna; et al.; A2; OA
- Most hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharpwave ripples and some do so in response to external stimulation and theta (2020) Nokia, Miriam S.; et al.; A1; OA
