A1 Journal article (refereed)
Radioactive Beams for Image-Guided Particle Therapy : The BARB Experiment at GSI (2021)

Boscolo, Daria, Kostyleva, Daria, Safari, Mohammad Javad, Anagnostatou, Vasiliki, Äystö, Juha, Bagchi, Soumya, Binder, Tim, Dedes, Georgios, Dendooven, Peter, Dickel, Timo, Drozd, Vasyl, Franczack, Bernhard, Geissel, Hans, Gianoli, Chiara, Graeff, Christian, Grahn, Tuomas, Greiner, Florian, Haettner, Emma, Haghani, Roghieh, Harakeh, Muhsin N., Horst, Felix, Hornung, Christine, Hucka, Jan-Paul, Kalantar-Nayestanaki, Nasser, Kazantseva, Erika, Kindler, Birgit, Knöbel, Ronja, Kuzminchuk-Feuerstein, Natalia, Lommel, Bettina, Mukha, Ivan, Nociforo, Chiara, Ishikawa, Shunki, Lovatti, Giulio, Nitta, Munetaka, Ozoemelam, Ikechi, Pietri, Stephane, Plaß, Wolfgang R., Prochazka, Andrej, Purushothaman, Sivaji, Reidel, Claire-Anne, Roesch, Heidi, Schirru, Fabio, Schuy, Christoph, Sokol, Olga, Steinsberger, Timo, Tanaka, Yoshiki K., Tanihata, Isao, Thirolf, Peter, Tinganelli, Walter, Voss, Bernd, Weber, Uli, Weick, Helmut, Winfield, John S., Winkler, Martin, Zhao, Jianwei, Scheidenberger, Christoph, Parodi, Katia, Durante, Marco, Super-FRS Experiment Collaboration. (2021). Radioactive Beams for Image-Guided Particle Therapy : The BARB Experiment at GSI. Frontiers in Oncology, 11, Article 737050. https://doi.org/10.3389/fonc.2021.737050

JYU authors or editors

Publication details

All authors or editors: Boscolo, Daria; Kostyleva, Daria; Safari, Mohammad Javad; Anagnostatou, Vasiliki; Äystö, Juha; Bagchi, Soumya; Binder, Tim; Dedes, Georgios; Dendooven, Peter; Dickel, Timo; et al.

Journal or series: Frontiers in Oncology

eISSN: 2234-943X

Publication year: 2021

Publication date: 19/08/2021

Volume: 11

Article number: 737050

Publisher: Frontiers Media SA

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3389/fonc.2021.737050

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/77457


Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Keywords: particle radiation; ions; positrons; medical physics; positron emission tomography; imaging; radiotherapy

Free keywords: particle therapy; radioactive ion beams; carbon ions; oxygen ions; PET

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 1

Last updated on 2022-20-09 at 14:25