A1 Journal article (refereed)
Radioactive Beams for Image-Guided Particle Therapy : The BARB Experiment at GSI (2021)


Boscolo, Daria, Kostyleva, Daria, Safari, Mohammad Javad, Anagnostatou, Vasiliki, Äystö, Juha, Bagchi, Soumya, Binder, Tim, Dedes, Georgios, Dendooven, Peter, Dickel, Timo, Drozd, Vasyl, Franczack, Bernhard, Geissel, Hans, Gianoli, Chiara, Graeff, Christian, Grahn, Tuomas, Greiner, Florian, Haettner, Emma, Haghani, Roghieh, Harakeh, Muhsin N., Horst, Felix, Hornung, Christine, Hucka, Jan-Paul, Kalantar-Nayestanaki, Nasser, Kazantseva, Erika, Kindler, Birgit, Knöbel, Ronja, Kuzminchuk-Feuerstein, Natalia, Lommel, Bettina, Mukha, Ivan, Nociforo, Chiara, Ishikawa, Shunki, Lovatti, Giulio, Nitta, Munetaka, Ozoemelam, Ikechi, Pietri, Stephane, Plaß, Wolfgang R., Prochazka, Andrej, Purushothaman, Sivaji, Reidel, Claire-Anne, Roesch, Heidi, Schirru, Fabio, Schuy, Christoph, Sokol, Olga, Steinsberger, Timo, Tanaka, Yoshiki K., Tanihata, Isao, Thirolf, Peter, Tinganelli, Walter, Voss, Bernd, Weber, Uli, Weick, Helmut, Winfield, John S., Winkler, Martin, Zhao, Jianwei, Scheidenberger, Christoph, Parodi, Katia, Durante, Marco, Super-FRS Experiment Collaboration. (2021). Radioactive Beams for Image-Guided Particle Therapy : The BARB Experiment at GSI. Frontiers in Oncology, 11, Article 737050. https://doi.org/10.3389/fonc.2021.737050


JYU authors or editors


Publication details

All authors or editorsBoscolo, Daria; Kostyleva, Daria; Safari, Mohammad Javad; Anagnostatou, Vasiliki; Äystö, Juha; Bagchi, Soumya; Binder, Tim; Dedes, Georgios; Dendooven, Peter; Dickel, Timo; et al.

Journal or seriesFrontiers in Oncology

eISSN2234-943X

Publication year2021

Publication date19/08/2021

Volume11

Article number737050

PublisherFrontiers Media SA

Publication countrySwitzerland

Publication languageEnglish

DOIhttps://doi.org/10.3389/fonc.2021.737050

Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/77457


Abstract

Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.


Keywordsparticle radiationionspositronsmedical physicspositron emission tomographyimagingradiotherapy

Free keywordsparticle therapy; radioactive ion beams; carbon ions; oxygen ions; PET


Contributing organizations


Ministry reportingYes

Reporting Year2021

JUFO rating1


Last updated on 2024-26-03 at 09:20