A1 Journal article (refereed)
Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture (2021)
Huuska, N., Netti, E., Tulamo, R., Lehti, S., Jahromi, B. R., Kovanen, P. T., & Niemelä, M. (2021). Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture. Journal of Neuropathology and Experimental Neurology, 80(10), 966-974. https://doi.org/10.1093/jnen/nlab086
JYU authors or editors
Publication details
All authors or editors: Huuska, Nora; Netti, Eliisa; Tulamo, Riikka; Lehti, Satu; Jahromi, Behnam Rezai; Kovanen, Petri T; Niemelä, Mika
Journal or series: Journal of Neuropathology and Experimental Neurology
ISSN: 0022-3069
eISSN: 1554-6578
Publication year: 2021
Publication date: 17/09/2021
Volume: 80
Issue number: 10
Pages range: 966-974
Publisher: Oxford University Press
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1093/jnen/nlab086
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82844
Abstract
Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Serum amyloid A (SAA) is an acute-phase protein produced in response to acute and chronic inflammation and tissue damage. Here, we studied the presence and the potential role of SAA in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), that had previously been studied by histology and immunohistochemistry. SAA was present in all sIAs, but the extent of immunopositivity varied greatly. SAA immunopositivity correlated with wall degeneration (p = 0.028) and rupture (p = 0.004), with numbers of CD163-positive and CD68-positive macrophages and CD3-positive T lymphocytes (all p < 0.001), and with the expression of myeloperoxidase, matrix metalloproteinase-9, prostaglandin E-2 receptor, and cyclo-oxygenase 2 in the sIA wall. Moreover, SAA positivity correlated with the accumulation of apolipoproteins A-1 and B-100. In conclusion, SAA occurs in the sIA wall and, as an inflammation-related factor, may contribute to the development of a rupture-prone sIA.
Keywords: vascular diseases; aneurysm; intracranial aneurysm; biomarkers; inflammation; lipoproteins; apolipoproteins
Free keywords: Saccular intracranial aneurysm; Serum amyloid A
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2021
JUFO rating: 1