A1 Journal article (refereed)
Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture (2021)

Huuska, N., Netti, E., Tulamo, R., Lehti, S., Jahromi, B. R., Kovanen, P. T., & Niemelä, M. (2021). Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture. Journal of Neuropathology and Experimental Neurology, 80(10), 966-974. https://doi.org/10.1093/jnen/nlab086

JYU authors or editors

Publication details

All authors or editors: Huuska, Nora; Netti, Eliisa; Tulamo, Riikka; Lehti, Satu; Jahromi, Behnam Rezai; Kovanen, Petri T; Niemelä, Mika

Journal or series: Journal of Neuropathology and Experimental Neurology

ISSN: 0022-3069

eISSN: 1554-6578

Publication year: 2021

Publication date: 17/09/2021

Volume: 80

Issue number: 10

Pages range: 966-974

Publisher: Oxford University Press

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1093/jnen/nlab086

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82844


Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Serum amyloid A (SAA) is an acute-phase protein produced in response to acute and chronic inflammation and tissue damage. Here, we studied the presence and the potential role of SAA in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), that had previously been studied by histology and immunohistochemistry. SAA was present in all sIAs, but the extent of immunopositivity varied greatly. SAA immunopositivity correlated with wall degeneration (p = 0.028) and rupture (p = 0.004), with numbers of CD163-positive and CD68-positive macrophages and CD3-positive T lymphocytes (all p < 0.001), and with the expression of myeloperoxidase, matrix metalloproteinase-9, prostaglandin E-2 receptor, and cyclo-oxygenase 2 in the sIA wall. Moreover, SAA positivity correlated with the accumulation of apolipoproteins A-1 and B-100. In conclusion, SAA occurs in the sIA wall and, as an inflammation-related factor, may contribute to the development of a rupture-prone sIA.

Keywords: vascular diseases; aneurysm; intracranial aneurysm; biomarkers; inflammation; lipoproteins; apolipoproteins

Free keywords: Saccular intracranial aneurysm; Serum amyloid A

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 1

Last updated on 2022-26-08 at 10:16