A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The Association Between Epigenetic Clocks and Physical Functioning in Older Women : A 3-Year Follow-up (2022)

Föhr, T., Törmäkangas, T., Lankila, H., Viljanen, A., Rantanen, T., Ollikainen, M., Kaprio, J., & Sillanpää, E. (2022). The Association Between Epigenetic Clocks and Physical Functioning in Older Women : A 3-Year Follow-up. Journals of Gerontology Series A : Biological Sciences and Medical Sciences, 77(8), 1569-1576. https://doi.org/10.1093/gerona/glab270

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Föhr, Tiina; Törmäkangas, Timo; Lankila, Hannamari; Viljanen, Anne; Rantanen, Taina; Ollikainen, Miina; Kaprio, Jaakko; Sillanpää, Elina

Lehti tai sarja: Journals of Gerontology Series A : Biological Sciences and Medical Sciences

ISSN: 1079-5006

eISSN: 1758-535X

Julkaisuvuosi: 2022

Ilmestymispäivä: 20.09.2021

Volyymi: 77

Lehden numero: 8

Artikkelin sivunumerot: 1569-1576

Kustantaja: Oxford University Press

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1093/gerona/glab270

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/82771


Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between four epigenetic clocks (Horvath’s and Hannum’s DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a three-year follow-up.

We studied 63–76-year-old women (n = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel) i.e. discrepancy between chronological age and DNAm age was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at baseline and at follow-up. A cross-sectional analysis was performed with path models, and a longitudinal analysis was conducted with repeated measures linear models. A nonrandom missing data analysis was performed.

In comparison to the other clocks, GrimAgeAccel was more strongly associated with physical functioning. At baseline, GrimAgeAccel was associated with lower performance in the Timed Up and Go (TUG) test and the six-minute walk test. At follow-up, significant associations were observed between GrimAgeAccel and lowered performance in the TUG, six-minute and 10-meter walk tests, and knee extension and ankle plantar flexion strength tests.

The DNAm GrimAge, a novel estimate of biological aging, associated with decline in physical functioning over the three-year follow-up in older women. However, associations between chronological age and physical function phenotypes followed similar pattern. Current epigenetic clocks do not provide strong benefits in predicting the decline of physical functioning at least during a rather short follow-up period and restricted age-range.

YSO-asiasanat: ikääntyminen; epigenetiikka; DNA-metylaatio; fyysinen toimintakyky

Vapaat asiasanat: epigenetic clock; biological aging

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2022

Alustava JUFO-taso: 3

Viimeisin päivitys 2023-03-04 klo 09:43