A2 Katsausartikkeli tieteellisessä aikausilehdessä
Prospective Cancer Therapies Using Stimuli‐Responsive DNA Nanostructures (2021)
Seitz, I., Shaukat, A., Nurmi, K., Ijäs, H., Hirvonen, J., Santos, H. A., Kostiainen, M. A., & Linko, V. (2021). Prospective Cancer Therapies Using Stimuli‐Responsive DNA Nanostructures. Macromolecular Bioscience, 21(12), Article 2100272. https://doi.org/10.1002/mabi.202100272
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Seitz, Iris; Shaukat, Ahmed; Nurmi, Kurt; Ijäs, Heini; Hirvonen, Jouni; Santos, Hélder A.; Kostiainen, Mauri A.; Linko, Veikko
Lehti tai sarja: Macromolecular Bioscience
ISSN: 1616-5187
eISSN: 1616-5195
Julkaisuvuosi: 2021
Ilmestymispäivä: 06.10.2021
Volyymi: 21
Lehden numero: 12
Artikkelinumero: 2100272
Kustantaja: Wiley-VCH Verlag
Julkaisumaa: Saksa
Julkaisun kieli: englanti
DOI: https://doi.org/10.1002/mabi.202100272
Julkaisun avoin saatavuus: Ei avoin
Julkaisukanavan avoin saatavuus:
Tiivistelmä
Nanostructures based on DNA self-assembly present an innovative way to address the increasing needs for target-specific delivery of therapeutic molecules. Currently, most of the chemotherapeutics being used in clinical practice have undesired and exceedingly high off-target toxicity. This is a challenge in particular for small molecules, and hence, developing robust and effective methods to lower these side effects and enhance the antitumor activity is of paramount importance. Prospectively, these issues could be tackled with the help of DNA nanotechnology, which provides a route for fabrication of custom, biocompatible, and multimodal structures, which can, to some extent, resist nuclease degradation and survive in cellular environment. Similar to widely employed liposomal products, the DNA nanostructures (DNs) are loaded with selected drugs, and then by employing a specific stimulus, the payload can be released at its target region. In this review, we explore several strategies and triggers to achieve targeted delivery of DNs. Notably, we explain different modalities through which DNs can interact with their respective targets as well as how structural changes triggered by external stimuli can be used to achieve the display or release of the cargo. Furthermore, we highlight the prospects and challenges of this technology.
YSO-asiasanat: syöpähoidot; lääkehoito; nanolääketiede; nanorakenteet; DNA
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2021
JUFO-taso: 1
