A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Towards early risk biomarkers : serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood (2021)

Ojanen, X., Cheng, R., Törmäkangas, T., Rappaport, N., Wilmanski, T., Wu, N., Fung, E., Nedelec, R., Sebert, S., Vlachopoulos, D., Yan, W., Price, N. D., Cheng, S., & Wiklund, P. (2021). Towards early risk biomarkers : serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood. EBioMedicine, 72, Article 103611. https://doi.org/10.1016/j.ebiom.2021.103611

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Ojanen, Xiaowei; Cheng, Runtan; Törmäkangas, Timo; Rappaport, Noa; Wilmanski, Tomasz; Wu, Na; Fung, Erik; Nedelec, Rozenn; Sebert, Sylvain; Vlachopoulos, Dimitris; et al.

Lehti tai sarja: EBioMedicine

ISSN: 2352-3964

eISSN: 2352-3964

Julkaisuvuosi: 2021

Volyymi: 72

Artikkelinumero: 103611

Kustantaja: Elsevier

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.ebiom.2021.103611

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78240

Lisätietoja: Available at SSRN: https://ssrn.com/abstract=3782500 or http://dx.doi.org/10.2139/ssrn.3782500


Cardiovascular diseases may originate in childhood. Biomarkers identifying individuals with increased risk for disease are needed to support early detection and to optimise prevention strategies.

In this prospective study, by applying a machine learning to high throughput NMR-based metabolomics data, we identified circulating childhood metabolic predictors of adult cardiovascular disease risk (MetS score) in a cohort of 396 females, followed from childhood (mean age 11·2 years) to early adulthood (mean age 18·1 years). The results obtained from the discovery cohort were validated in a large longitudinal birth cohort of females and males followed from puberty to adulthood (n = 2664) and in four cross-sectional data sets (n = 6341).

The identified childhood metabolic signature included three circulating biomarkers, glycoprotein acetyls (GlycA), large high-density lipoprotein phospholipids (L-HDL-PL), and the ratio of apolipoprotein B to apolipoprotein A-1 (ApoB/ApoA) that were associated with increased cardio-metabolic risk in early adulthood (AUC = 0·641‒0·802, all p<0·01). These associations were confirmed in all validation cohorts with similar effect estimates both in females (AUC = 0·667‒0·905, all p<0·01) and males (AUC = 0·734‒0·889, all p<0·01) as well as in elderly patients with and without type 2 diabetes (AUC = 0·517‒0·700, all p<0·01). We subsequently applied random intercept cross-lagged panel model analysis, which suggested bidirectional causal relationship between metabolic biomarkers and cardio-metabolic risk score from childhood to early adulthood.

These results provide evidence for the utility of a circulating metabolomics panel to identify children and adolescents at risk for future cardiovascular disease, to whom preventive measures and follow-up could be indicated.

YSO-asiasanat: sydän- ja verisuonitaudit; riskitekijät; biomarkkerit; aineenvaihduntatuotteet; lapsuus; aikuisuus; pitkittäistutkimus

Vapaat asiasanat: metabolomics; cardio-metabolic risk; children; longitudinal-study; ALSPAC

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2021

JUFO-taso: 1

Viimeisin päivitys 2022-14-09 klo 11:46