A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases (2022)
Sillanpää, E., Palviainen, T., Ripatti, S., Kujala, U. M., & Kaprio, J. (2022). Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases. Medicine and Science in Sports and Exercise, 54(2), 280-287. https://doi.org/10.1249/MSS.0000000000002788
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Sillanpää, Elina; Palviainen, Teemu; Ripatti, Samuli; Kujala, Urho M.; Kaprio, Jaakko
Lehti tai sarja: Medicine and Science in Sports and Exercise
ISSN: 0195-9131
eISSN: 1530-0315
Julkaisuvuosi: 2022
Ilmestymispäivä: 20.09.2021
Volyymi: 54
Lehden numero: 2
Artikkelin sivunumerot: 280-287
Kustantaja: Lippincott Williams & Wilkins; American College of Sports Medicine
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1249/MSS.0000000000002788
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/79402
Tiivistelmä
Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.
Methods
PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Associations between PA PRS and body mass index (BMI), diseases, and mortality were analysed with linear and logistic regression models.
Results
A high PA PRS predicted a lower BMI (β -0.025 kg/m2 per one standard deviation (SD) change in PA PRS, SE 0.013, p = 1.87x10-80). The PA PRS also predicted a lower risk for diseases that typically develop later in life or not at all among highly active individuals. A lower disease risk was systematically observed for cardiovascular diseases [odds ratio, OR per 1 SD change in PA PRS 0.95, p = 9.5*10-19) and, for example, hypertension [OR 0.93, p = 2.7*10-44), type 2 diabetes (OR 0.91, p = 4.1*10-42), and coronary heart disease (OR 0.95 p = 1.2*10-9). Participants with high PA PRS had also lower mortality risk (OR 0.97, p = 0.0003).
Conclusions
Genetically less active persons are at a higher risk of developing cardiometabolic diseases, which may partly explain the previously observed associations between low PA and higher disease and mortality risk. The same inherited physical fitness and metabolism related mechanisms may be associated both with PA levels and with cardiometabolic disease risk.
YSO-asiasanat: fyysinen aktiivisuus; sydän- ja verisuonitaudit; sairastavuus; kuolleisuus; riskitekijät; geneettiset tekijät; kohorttitutkimus; pitkittäistutkimus
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 3
