A1 Journal article (refereed)
Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases (2022)
Sillanpää, E., Palviainen, T., Ripatti, S., Kujala, U. M., & Kaprio, J. (2022). Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases. Medicine and Science in Sports and Exercise, 54(2), 280-287. https://doi.org/10.1249/MSS.0000000000002788
JYU authors or editors
Publication details
All authors or editors: Sillanpää, Elina; Palviainen, Teemu; Ripatti, Samuli; Kujala, Urho M.; Kaprio, Jaakko
Journal or series: Medicine and Science in Sports and Exercise
ISSN: 0195-9131
eISSN: 1530-0315
Publication year: 2022
Publication date: 20/09/2021
Volume: 54
Issue number: 2
Pages range: 280-287
Publisher: Lippincott Williams & Wilkins; American College of Sports Medicine
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1249/MSS.0000000000002788
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/79402
Abstract
Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.
Methods
PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Associations between PA PRS and body mass index (BMI), diseases, and mortality were analysed with linear and logistic regression models.
Results
A high PA PRS predicted a lower BMI (β -0.025 kg/m2 per one standard deviation (SD) change in PA PRS, SE 0.013, p = 1.87x10-80). The PA PRS also predicted a lower risk for diseases that typically develop later in life or not at all among highly active individuals. A lower disease risk was systematically observed for cardiovascular diseases [odds ratio, OR per 1 SD change in PA PRS 0.95, p = 9.5*10-19) and, for example, hypertension [OR 0.93, p = 2.7*10-44), type 2 diabetes (OR 0.91, p = 4.1*10-42), and coronary heart disease (OR 0.95 p = 1.2*10-9). Participants with high PA PRS had also lower mortality risk (OR 0.97, p = 0.0003).
Conclusions
Genetically less active persons are at a higher risk of developing cardiometabolic diseases, which may partly explain the previously observed associations between low PA and higher disease and mortality risk. The same inherited physical fitness and metabolism related mechanisms may be associated both with PA levels and with cardiometabolic disease risk.
Keywords: physical activity; cardiovascular diseases; prevalence of a condition; mortality; risk factors; genetic factors; cohort study; longitudinal research
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2022
JUFO rating: 3
