A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases (2022)


Sillanpää, E., Palviainen, T., Ripatti, S., Kujala, U. M., & Kaprio, J. (2022). Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases. Medicine and Science in Sports and Exercise, 54(2), 280-287. https://doi.org/10.1249/MSS.0000000000002788


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Sillanpää, Elina; Palviainen, Teemu; Ripatti, Samuli; Kujala, Urho M.; Kaprio, Jaakko

Lehti tai sarja: Medicine and Science in Sports and Exercise

ISSN: 0195-9131

eISSN: 1530-0315

Julkaisuvuosi: 2022

Ilmestymispäivä: 20.09.2021

Volyymi: 54

Lehden numero: 2

Artikkelin sivunumerot: 280-287

Kustantaja: Lippincott Williams & Wilkins; American College of Sports Medicine

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1249/MSS.0000000000002788

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/79402


Tiivistelmä

Introduction
Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.

Methods
PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Associations between PA PRS and body mass index (BMI), diseases, and mortality were analysed with linear and logistic regression models.

Results
A high PA PRS predicted a lower BMI (β -0.025 kg/m2 per one standard deviation (SD) change in PA PRS, SE 0.013, p = 1.87x10-80). The PA PRS also predicted a lower risk for diseases that typically develop later in life or not at all among highly active individuals. A lower disease risk was systematically observed for cardiovascular diseases [odds ratio, OR per 1 SD change in PA PRS 0.95, p = 9.5*10-19) and, for example, hypertension [OR 0.93, p = 2.7*10-44), type 2 diabetes (OR 0.91, p = 4.1*10-42), and coronary heart disease (OR 0.95 p = 1.2*10-9). Participants with high PA PRS had also lower mortality risk (OR 0.97, p = 0.0003).

Conclusions
Genetically less active persons are at a higher risk of developing cardiometabolic diseases, which may partly explain the previously observed associations between low PA and higher disease and mortality risk. The same inherited physical fitness and metabolism related mechanisms may be associated both with PA levels and with cardiometabolic disease risk.


YSO-asiasanat: fyysinen aktiivisuus; sydän- ja verisuonitaudit; sairastavuus; kuolleisuus; riskitekijät; geneettiset tekijät; kohorttitutkimus; pitkittäistutkimus


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2022

Alustava JUFO-taso: 3


Viimeisin päivitys 2022-20-09 klo 13:47