A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept (2021)
Pinto, A., Roma-Rodrigues, C., Ward, J. S., Puttreddy, R., Rissanen, K., Baptista, P. V., Fernandes, A. R., Lima João, C., & Rodríguez, L. (2021). Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept. Inorganic Chemistry, 60(24), 18753-18763. https://doi.org/10.1021/acs.inorgchem.1c02359
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Pinto, Andrea; Roma-Rodrigues, Catarina; Ward, Jas S.; Puttreddy, Rakesh; Rissanen, Kari; Baptista, Pedro V.; Fernandes, Alexandra R.; Lima João, Carlos; Rodríguez, Laura
Lehti tai sarja: Inorganic Chemistry
ISSN: 0020-1669
eISSN: 1520-510X
Julkaisuvuosi: 2021
Ilmestymispäivä: 01.11.2021
Volyymi: 60
Lehden numero: 24
Artikkelin sivunumerot: 18753-18763
Kustantaja: American Chemical Society (ACS)
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1021/acs.inorgchem.1c02359
Julkaisun avoin saatavuus: Ei avoin
Julkaisukanavan avoin saatavuus: Julkaisukanava ei ole avoin
Tiivistelmä
The aggregation process of a series of mono- and dinuclear gold(I) complexes containing a 4-ethynylaniline ligand and a phosphane at the second coordination position (PR3-Au-C≡CC6H4-NH2, complexes 1–5, and (diphos)(Au-C≡CC6H4-NH2)2, complexes 6–8), whose biological activity was previously studied by us, has been carefully analyzed through absorption, emission, and NMR spectroscopy, together with dynamic light scattering and small-angle X-ray scattering. These experiments allow us to retrieve information about how the compounds enter the cells. It was observed that all compounds present aggregation in fresh solutions, before biological treatment, and thus they must be entering the cells as aggregates. Inductively coupled plasma atomic emission spectrometry measurements showed that mononuclear complexes are mainly found in the cytosolic fraction; the dinuclear complexes are mainly found in a subsequent fraction composed of nuclei and cytoskeleton. Additionally, dinuclear complex 8 affects the actin aggregation to a larger extent, suggesting a cooperative effect of dinuclear compounds.
YSO-asiasanat: kulta; biologinen aktiivisuus; solut; aggregointi; kemialliset yhdisteet; kidetiede; röntgenkristallografia; NMR-spektroskopia; biokemia; lääkeaineet
Vapaat asiasanat: X-rays; gold; crystal structure; group 15 compounds; aggregation
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2021
JUFO-taso: 2
