A1 Journal article (refereed)
Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept (2021)


Pinto, A., Roma-Rodrigues, C., Ward, J. S., Puttreddy, R., Rissanen, K., Baptista, P. V., Fernandes, A. R., Lima João, C., & Rodríguez, L. (2021). Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept. Inorganic Chemistry, 60(24), 18753-18763. https://doi.org/10.1021/acs.inorgchem.1c02359


JYU authors or editors


Publication details

All authors or editors: Pinto, Andrea; Roma-Rodrigues, Catarina; Ward, Jas S.; Puttreddy, Rakesh; Rissanen, Kari; Baptista, Pedro V.; Fernandes, Alexandra R.; Lima João, Carlos; Rodríguez, Laura

Journal or series: Inorganic Chemistry

ISSN: 0020-1669

eISSN: 1520-510X

Publication year: 2021

Publication date: 01/11/2021

Volume: 60

Issue number: 24

Pages range: 18753-18763

Publisher: American Chemical Society (ACS)

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.inorgchem.1c02359

Publication open access: Not open

Publication channel open access: Channel is not openly available


Abstract

The aggregation process of a series of mono- and dinuclear gold(I) complexes containing a 4-ethynylaniline ligand and a phosphane at the second coordination position (PR3-Au-C≡CC6H4-NH2, complexes 1–5, and (diphos)(Au-C≡CC6H4-NH2)2, complexes 6–8), whose biological activity was previously studied by us, has been carefully analyzed through absorption, emission, and NMR spectroscopy, together with dynamic light scattering and small-angle X-ray scattering. These experiments allow us to retrieve information about how the compounds enter the cells. It was observed that all compounds present aggregation in fresh solutions, before biological treatment, and thus they must be entering the cells as aggregates. Inductively coupled plasma atomic emission spectrometry measurements showed that mononuclear complexes are mainly found in the cytosolic fraction; the dinuclear complexes are mainly found in a subsequent fraction composed of nuclei and cytoskeleton. Additionally, dinuclear complex 8 affects the actin aggregation to a larger extent, suggesting a cooperative effect of dinuclear compounds.


Keywords: gold; biological activity; cells; aggregation; chemical compounds; crystallography; x-ray crystallography; NMR spectroscopy; biochemistry; medicinal substances

Free keywords: X-rays; gold; crystal structure; group 15 compounds; aggregation


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 2


Last updated on 2022-19-08 at 19:31