A1 Journal article (refereed)
Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept (2021)


Pinto, A., Roma-Rodrigues, C., Ward, J. S., Puttreddy, R., Rissanen, K., Baptista, P. V., Fernandes, A. R., Lima João, C., & Rodríguez, L. (2021). Aggregation versus Biological Activity in Gold(I) Complexes : An Unexplored Concept. Inorganic Chemistry, 60(24), 18753-18763. https://doi.org/10.1021/acs.inorgchem.1c02359


JYU authors or editors


Publication details

All authors or editorsPinto, Andrea; Roma-Rodrigues, Catarina; Ward, Jas S.; Puttreddy, Rakesh; Rissanen, Kari; Baptista, Pedro V.; Fernandes, Alexandra R.; Lima João, Carlos; Rodríguez, Laura

Journal or seriesInorganic Chemistry

ISSN0020-1669

eISSN1520-510X

Publication year2021

Publication date01/11/2021

Volume60

Issue number24

Pages range18753-18763

PublisherAmerican Chemical Society (ACS)

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.inorgchem.1c02359

Publication open accessNot open

Publication channel open accessChannel is not openly available


Abstract

The aggregation process of a series of mono- and dinuclear gold(I) complexes containing a 4-ethynylaniline ligand and a phosphane at the second coordination position (PR3-Au-C≡CC6H4-NH2, complexes 1–5, and (diphos)(Au-C≡CC6H4-NH2)2, complexes 6–8), whose biological activity was previously studied by us, has been carefully analyzed through absorption, emission, and NMR spectroscopy, together with dynamic light scattering and small-angle X-ray scattering. These experiments allow us to retrieve information about how the compounds enter the cells. It was observed that all compounds present aggregation in fresh solutions, before biological treatment, and thus they must be entering the cells as aggregates. Inductively coupled plasma atomic emission spectrometry measurements showed that mononuclear complexes are mainly found in the cytosolic fraction; the dinuclear complexes are mainly found in a subsequent fraction composed of nuclei and cytoskeleton. Additionally, dinuclear complex 8 affects the actin aggregation to a larger extent, suggesting a cooperative effect of dinuclear compounds.


Keywordsgoldbiological activitycellsaggregationchemical compoundscrystallographyx-ray crystallographyNMR spectroscopybiochemistrymedicinal substances

Free keywordsX-rays; gold; crystal structure; group 15 compounds; aggregation


Contributing organizations


Ministry reportingYes

Reporting Year2021

JUFO rating2


Last updated on 2024-03-04 at 17:45