A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Metabolic health, menopause, and physical activity : a 4-year follow-up study (2022)

Hyvärinen, M., Juppi, H.-K., Taskinen, S., Karppinen, J. E., Karvinen, S., Tammelin, T. H., Kovanen, V., Aukee, P., Kujala, U. M., Rantalainen, T., Sipilä, S., & Laakkonen, E. K. (2022). Metabolic health, menopause, and physical activity : a 4-year follow-up study. International Journal of Obesity, 46(3), 544-554. https://doi.org/10.1038/s41366-021-01022-x

JYU-tekijät tai -toimittajat

Hyvärinen, Matti
Juppi, Hanna-Kaarina
Taskinen, Sara
Karppinen, Jari
Karvinen, Sira
Kovanen, Vuokko
Kujala, Urho
Rantalainen, Timo
Sipilä, Sarianna
Laakkonen, Eija

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Hyvärinen, Matti; Juppi, Hanna-Kaarina; Taskinen, Sara; Karppinen, Jari E.; Karvinen, Sira; Tammelin, Tuija H.; Kovanen, Vuokko; Aukee, Pauliina; Kujala, Urho M.; Rantalainen, Timo; et al.

Lehti tai sarja: International Journal of Obesity

ISSN: 0307-0565

eISSN: 1476-5497

Julkaisuvuosi: 2022

Ilmestymispäivä: 20.11.2021

Volyymi: 46

Lehden numero: 3

Artikkelin sivunumerot: 544-554

Kustantaja: Nature Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1038/s41366-021-01022-x

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78775

Tiivistelmä

Background
In women, metabolic health deteriorates after menopause, and the role of physical activity (PA) in mitigating the change is not completely understood. This study investigates the changes in indicators of metabolic health around menopause and evaluates whether PA modulates these changes.

Methods
Longitudinal data of 298 women aged 48–55 years at baseline participating in the ERMA and EsmiRs studies was used. Mean follow-up time was 3.8 (SD 0.1) years. Studied indicators of metabolic health were total and android fat mass, waist circumference, waist-to-hip ratio (WHR), systolic (SBP) and diastolic (DBP) blood pressure, blood glucose, triglycerides, serum total cholesterol, and high- (HDL-C) and low-density (LDL-C) lipoprotein cholesterol. PA was assessed by accelerometers and questionnaires. The participants were categorized into three menopausal groups: PRE-PRE (pre- or perimenopausal at both timepoints, n = 56), PRE-POST (pre- or perimenopausal at baseline, postmenopausal at follow-up, n = 149), and POST-POST (postmenopausal at both timepoints, n = 93). Analyses were carried out using linear and Poisson mixed-effect models.

Results
At baseline, PA associated directly with HDL-C and inversely with LDL-C and all body adiposity variables. An increase was observed in total (B = 1.72, 95% CI [0.16, 3.28]) and android fat mass (0.26, [0.06, 0.46]), SBP (9.37, [3.34, 15.39]), and in all blood-based biomarkers in the PRE-POST group during the follow-up. The increase tended to be smaller in the PRE-PRE and POST-POST groups compared to the PRE-POST group, except for SBP. The change in PA associated inversely with the change in SBP (−2.40, [−4.34, −0.46]) and directly with the change in WHR (0.72, [0.05, 1.38]).

Conclusions
In middle-aged women, menopause may accelerate the changes in multiple indicators of metabolic health. PA associates with healthier blood lipid profile and body composition in middle-aged women but does not seem to modulate the changes in most of the studied metabolic health indicators during the menopausal transition.

YSO-asiasanat: vaihdevuodet; metabolinen oireyhtymä; riskitekijät; fyysinen aktiivisuus; seurantatutkimus

Vapaat asiasanat: metabolic syndrome; risk factors

Tieteenalat: