A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides (2021)


Kuosmanen, R. T., Truong, K., Rissanen, K. T., & Sievänen, E. I. (2021). The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides. ChemistryOpen, 10(11), 1150-1157. https://doi.org/10.1002/open.202100245


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Kuosmanen, Riikka T.; Truong, Khai‐Nghi; Rissanen, Kari T.; Sievänen, Elina I.

Lehti tai sarja: ChemistryOpen

eISSN: 2191-1363

Julkaisuvuosi: 2021

Volyymi: 10

Lehden numero: 11

Artikkelin sivunumerot: 1150-1157

Kustantaja: Wiley-VCH Verlag

Julkaisumaa: Saksa

Julkaisun kieli: englanti

DOI: https://doi.org/10.1002/open.202100245

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78820


Tiivistelmä

Six bile acid alkyl amide derivatives were studied with respect to their gelation properties. The derivatives were composed of three different bile acids with hexyl or cyclohexyl side chains. The gelation behaviour of all six compounds were studied for 36 solvents with varying polarities. Gelation was observed mainly in aromatic solvents, which is characteristic for bile-acid-based low molecular weight gelators. Out of 108 bile acid-solvent combinations, a total of 44 gel systems were formed, 28 of which from lithocholic acid derivatives, only two from deoxycholic acid derivatives, and 14 from cholic acid derivatives. The majority of the gel systems were formed from bile acids with hexyl side chains, contrary to the cyclohexyl group, which seems to be a poor gelation moiety. These results indicate that the spatial demand of the side chain is the key feature for the gelation properties of the bile acid amides.


YSO-asiasanat: amidit; sappihapot; geelit; supramolekulaarinen kemia; röntgenkristallografia

Vapaat asiasanat: bile acid amides; intermolecular interactions; solvent influence; supramolecular gels; X-ray crystallography


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OKM-raportointi: Kyllä

Alustava JUFO-taso: 1


Viimeisin päivitys 2022-09-02 klo 07:57