A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Chaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit (2022)
Zand, A. M., Tavazoei, M. S., & Kuznetsov, N. V. (2022). Chaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit. IEEE Control Systems Letters, 6, 1622-1627. https://doi.org/10.1109/LCSYS.2021.3129320
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Zand, Armin M.; Tavazoei, Mohammad Saleh; Kuznetsov, Nikolay V.
Lehti tai sarja: IEEE Control Systems Letters
eISSN: 2475-1456
Julkaisuvuosi: 2022
Volyymi: 6
Artikkelin sivunumerot: 1622-1627
Kustantaja: Institute of Electrical and Electronics Engineers (IEEE)
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1109/LCSYS.2021.3129320
Julkaisun avoin saatavuus: Ei avoin
Julkaisukanavan avoin saatavuus:
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78876
Tiivistelmä
This letter deals with a novel variant of antithetic integral feedback controller (AIFC) motifs which can feature robust perfect adaptation, a pervasive (desired) ability in natural (synthetic) biomolecular circuits, when coupled with a wide class of process networks to be regulated. Using the separation of timescales in the proposed kind of AIFC, here we find a reducedorder controller that captures the governing slow part of the original solutions under suitable assumptions. Inspired by R(ossler systems, we then make use of such a simpler controller to show that the antithetic circuit can exhibit chaotic behaviors with strange attractors, where the bifurcation from a homeostatic state to chaotic orbits can happen, e.g., when considering saturated Hill-type reactions for the actuation. Addition of degradation terms to the controller species, whether naturally due to dilution or exogenously using protein tags, is showcased by simulation results to be an effective solution in suppressing deterministic chaos and aperiodic oscillations. In the same vein, we recapitulate the recently introduced antithetic rein IFC motif and confirm that the promotion of degradation by a rein mechanism also can control chaos and improve the stability of closed-loop circuit.
YSO-asiasanat: elektroniset piirit; oskillaattorit; mallit (mallintaminen); matemaattiset mallit; säätöteoria; kaaosteoria
Vapaat asiasanat: chaos; process control; degradation; mathematical models; oscillators; integrated circuit modeling; biological system modeling
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 1