A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Chaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit (2022)

Zand, A. M., Tavazoei, M. S., & Kuznetsov, N. V. (2022). Chaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit. IEEE Control Systems Letters, 6, 1622-1627. https://doi.org/10.1109/LCSYS.2021.3129320

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Zand, Armin M.; Tavazoei, Mohammad Saleh; Kuznetsov, Nikolay V.

Lehti tai sarja: IEEE Control Systems Letters

eISSN: 2475-1456

Julkaisuvuosi: 2022

Volyymi: 6

Artikkelin sivunumerot: 1622-1627

Kustantaja: Institute of Electrical and Electronics Engineers (IEEE)

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1109/LCSYS.2021.3129320

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus:

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/78876


This letter deals with a novel variant of antithetic integral feedback controller (AIFC) motifs which can feature robust perfect adaptation, a pervasive (desired) ability in natural (synthetic) biomolecular circuits, when coupled with a wide class of process networks to be regulated. Using the separation of timescales in the proposed kind of AIFC, here we find a reducedorder controller that captures the governing slow part of the original solutions under suitable assumptions. Inspired by R(ossler systems, we then make use of such a simpler controller to show that the antithetic circuit can exhibit chaotic behaviors with strange attractors, where the bifurcation from a homeostatic state to chaotic orbits can happen, e.g., when considering saturated Hill-type reactions for the actuation. Addition of degradation terms to the controller species, whether naturally due to dilution or exogenously using protein tags, is showcased by simulation results to be an effective solution in suppressing deterministic chaos and aperiodic oscillations. In the same vein, we recapitulate the recently introduced antithetic rein IFC motif and confirm that the promotion of degradation by a rein mechanism also can control chaos and improve the stability of closed-loop circuit.

YSO-asiasanat: elektroniset piirit; oskillaattorit; mallit (mallintaminen); matemaattiset mallit; säätöteoria; kaaosteoria

Vapaat asiasanat: chaos; process control; degradation; mathematical models; oscillators; integrated circuit modeling; biological system modeling

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2022

Alustava JUFO-taso: 1

Viimeisin päivitys 2022-20-09 klo 15:47