A1 Journal article (refereed)
The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network (2021)

Selenius, J. S., Silveira, P. P., Salonen, M., Kautiainen, H., von Bonsdorff, M., Kajantie, E., Lahti, J., Eriksson, J. G., & Wasenius, N. S. (2021). The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network. Scientific Reports, 11, Article 21588. https://doi.org/10.1038/s41598-021-00631-w

JYU authors or editors

Publication details

All authors or editors: Selenius, Jannica S.; Silveira, Patricia P.; Salonen, Minna; Kautiainen, Hannu; von Bonsdorff, Mikaela; Kajantie, Eero; Lahti, Jari; Eriksson, Johan G.; Wasenius, Niko S.

Journal or series: Scientific Reports

eISSN: 2045-2322

Publication year: 2021

Publication date: 03/11/2021

Volume: 11

Article number: 21588

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s41598-021-00631-w

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/78871


To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7–7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = − 3.4, 95% CI − 5.6 to − 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.

Keywords: depression (mental disorders); risk factors; state of health; quality of life; glucose metabolism; diabetes; genetic factors

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2021

JUFO rating: 1

Last updated on 2022-14-09 at 11:58