A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat (2022)
Paasonen, E., Paasonen, J., Lehto, L. J., Pirttimäki, T., Laakso, H., Wu, L., Ma, J., Idiyatullin, D., Tanila, H., Mangia, S., Michaeli, S., & Gröhn, O. (2022). Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat. Magnetic Resonance in Medicine, 87(6), 2872-2884. https://doi.org/10.1002/mrm.29154
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J.; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; et al.
Lehti tai sarja: Magnetic Resonance in Medicine
ISSN: 0740-3194
eISSN: 1522-2594
Julkaisuvuosi: 2022
Ilmestymispäivä: 05.01.2022
Volyymi: 87
Lehden numero: 6
Artikkelin sivunumerot: 2872-2884
Kustantaja: John Wiley & Sons
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1002/mrm.29154
Julkaisun avoin saatavuus: Ei avoin
Julkaisukanavan avoin saatavuus:
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/84826
Julkaisu on rinnakkaistallennettu: https://erepo.uef.fi/handle/123456789/28513
Tiivistelmä
To develop a high temporal resolution functional MRI method for tracking repeating events in the brain.
Methods
We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution.
Results
The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution.
Conclusion
The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.
YSO-asiasanat: toiminnallinen magneettikuvaus; kuvantaminen; koe-eläinmallit
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 1
