A1 Journal article (refereed)
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat (2022)


Paasonen, E., Paasonen, J., Lehto, L. J., Pirttimäki, T., Laakso, H., Wu, L., Ma, J., Idiyatullin, D., Tanila, H., Mangia, S., Michaeli, S., & Gröhn, O. (2022). Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat. Magnetic Resonance in Medicine, 87(6), 2872-2884. https://doi.org/10.1002/mrm.29154


JYU authors or editors


Publication details

All authors or editors: Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J.; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; et al.

Journal or series: Magnetic Resonance in Medicine

ISSN: 0740-3194

eISSN: 1522-2594

Publication year: 2022

Publication date: 05/01/2022

Volume: 87

Issue number: 6

Pages range: 2872-2884

Publisher: John Wiley & Sons

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1002/mrm.29154

Publication open access: Not open

Publication channel open access:


Abstract

Purpose
To develop a high temporal resolution functional MRI method for tracking repeating events in the brain.

Methods
We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution.

Results
The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution.

Conclusion
The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.


Keywords: functional magnetic resonance imaging; imaging; animal disease models

Free keywords: DBS; fast imaging; fMRI; HRF; MB-SWIFT; MSN


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2022

Preliminary JUFO rating: 1


Last updated on 2022-19-08 at 20:17