A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat (2022)


Paasonen, E., Paasonen, J., Lehto, L. J., Pirttimäki, T., Laakso, H., Wu, L., Ma, J., Idiyatullin, D., Tanila, H., Mangia, S., Michaeli, S., & Gröhn, O. (2022). Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat. Magnetic Resonance in Medicine, 87(6), 2872-2884. https://doi.org/10.1002/mrm.29154


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J.; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; et al.

Lehti tai sarja: Magnetic Resonance in Medicine

ISSN: 0740-3194

eISSN: 1522-2594

Julkaisuvuosi: 2022

Ilmestymispäivä: 05.01.2022

Volyymi: 87

Lehden numero: 6

Artikkelin sivunumerot: 2872-2884

Kustantaja: John Wiley & Sons

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1002/mrm.29154

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus:


Tiivistelmä

Purpose
To develop a high temporal resolution functional MRI method for tracking repeating events in the brain.

Methods
We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution.

Results
The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution.

Conclusion
The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.


YSO-asiasanat: toiminnallinen magneettikuvaus; kuvantaminen; koe-eläinmallit

Vapaat asiasanat: DBS; fast imaging; fMRI; HRF; MB-SWIFT; MSN


Liittyvät organisaatiot

JYU-yksiköt:


OKM-raportointi: Kyllä

Raportointivuosi: 2022

Alustava JUFO-taso: 1


Viimeisin päivitys 2022-19-08 klo 20:17