A1 Journal article (refereed)
Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat (2022)
Paasonen, E., Paasonen, J., Lehto, L. J., Pirttimäki, T., Laakso, H., Wu, L., Ma, J., Idiyatullin, D., Tanila, H., Mangia, S., Michaeli, S., & Gröhn, O. (2022). Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat. Magnetic Resonance in Medicine, 87(6), 2872-2884. https://doi.org/10.1002/mrm.29154
JYU authors or editors
Publication details
All authors or editors: Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J.; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; et al.
Journal or series: Magnetic Resonance in Medicine
ISSN: 0740-3194
eISSN: 1522-2594
Publication year: 2022
Publication date: 05/01/2022
Volume: 87
Issue number: 6
Pages range: 2872-2884
Publisher: John Wiley & Sons
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1002/mrm.29154
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/84826
Publication is parallel published: https://erepo.uef.fi/handle/123456789/28513
Abstract
To develop a high temporal resolution functional MRI method for tracking repeating events in the brain.
Methods
We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution.
Results
The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution.
Conclusion
The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.
Keywords: functional magnetic resonance imaging; imaging; animal disease models
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2022
JUFO rating: 1
