A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age (2022)
Haapanen, M. J., Jylhävä, J., Kortelainen, L., Mikkola, T. M., Salonen, M., Wasenius, N. S., Kajantie, E., Eriksson, J. G., & von Bonsdorff, M. B. (2022). Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age. Journals of Gerontology Series A : Biological Sciences and Medical Sciences, 77(11), 2281-2287. https://doi.org/10.1093/gerona/glac007
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Haapanen, Markus J.; Jylhävä, Juulia; Kortelainen, Lauri; Mikkola, Tuija M.; Salonen, Minna; Wasenius, Niko S.; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B.
Lehti tai sarja: Journals of Gerontology Series A : Biological Sciences and Medical Sciences
ISSN: 1079-5006
eISSN: 1758-535X
Julkaisuvuosi: 2022
Ilmestymispäivä: 09.01.2022
Volyymi: 77
Lehden numero: 11
Artikkelin sivunumerot: 2281-2287
Kustantaja: Oxford University Press (OUP)
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1093/gerona/glac007
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/79411
Tiivistelmä
Early life exposures have been associated with the risk of frailty in old age. We investigated whether early life exposures predict the level and rate of change in a frailty index (FI) from midlife into old age.
Methods
A linear mixed model analysis was performed using data from three measurement occasions over 17 years in participants from the Helsinki Birth Cohort Study (n=2000) aged 57-84 years. A 41-item FI was calculated on each occasion. Information on birth size, maternal body mass index (BMI), growth in infancy and childhood, childhood socioeconomic status (SES), and early life stress (wartime separation from both parents), was obtained from registers and healthcare records.
Results
At age 57 years the mean FI level was 0.186 and the FI levels increased by 0.34 percent/year from midlife into old age. Larger body size at birth associated with a slower increase in FI levels from midlife into old age. Per 1kg greater birth weight the increase in FI levels per year was -0.087 percentage points slower (95% CI=-0.163, -0.011; p=0.026). Higher maternal BMI was associated with a higher offspring FI level in midlife and a slower increase in FI levels into old age. Larger size, faster growth from infancy to childhood, and low SES in childhood were all associated with a lower FI level in midlife but not with its rate of change.
Conclusions
Early life factors seem to contribute to disparities in frailty from midlife into old age. Early life factors may identify groups that could benefit from frailty prevention, optimally initiated early in life.
YSO-asiasanat: ikääntyminen; gerastenia; riskitekijät; elämänkaari; syntymäpaino; varhaislapsuus
Vapaat asiasanat: life course; risk factors; frailty; birth factors
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 3
