A2 Katsausartikkeli tieteellisessä aikausilehdessä
Exercise Medicine for Cancer Cachexia : Targeted Exercise to Counteract Mechanisms and Treatment Side Effects (2022)

Mavropalias, G., Sim, M., Taaffe, D., Galvão, D. A., Spry, N., Kraemer, W., Häkkinen, K., & Newton, R. (2022). Exercise Medicine for Cancer Cachexia : Targeted Exercise to Counteract Mechanisms and Treatment Side Effects. Journal of Cancer Research and Clinical Oncology, 148(6), 1389-1406. https://doi.org/10.1007/s00432-022-03927-0

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Mavropalias, Georgios; Sim, Marc; Taaffe, Dennis, R.; Galvão, Daniel A.; Spry, Nigel; Kraemer, William, J.; Häkkinen, Keijo; Newton, Robert, U.

Lehti tai sarja: Journal of Cancer Research and Clinical Oncology

ISSN: 0171-5216

eISSN: 1432-1335

Julkaisuvuosi: 2022

Ilmestymispäivä: 27.01.2022

Volyymi: 148

Lehden numero: 6

Artikkelin sivunumerot: 1389-1406

Kustantaja: Springer Science and Business Media LLC

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s00432-022-03927-0

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/79567

Tiivistelmä

Purpose -- Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most optimal form and dosage of exercise therapy specific to each underlying mechanism of CC. Methods -- The relevant literatures from MEDLINE and Scopus databases were examined. Results -- Exercise can counteract the most prominent mechanisms and signs of CC including muscle wasting, increased protein turnover, systemic inflammation, reduced appetite and anorexia, increased energy expenditure and fat wasting, insulin resistance, metabolic dysregulation, gut dysbiosis, hypogonadism, impaired oxidative capacity, mitochondrial dysfunction, and cancer treatments side-effects. There are different modes of exercise, and each mode has different sub-types that induce vastly diverse changes when performed over multiple sessions. Choosing suboptimal exercise modes, types, or dosages can be counterproductive and could further contribute to the mechanisms of CC without impacting muscle growth. Conclusion -- Available evidence shows that patients with CC can safely undertake higher-intensity resistance exercise programs, and benefit from increases in body mass and muscle mass.

YSO-asiasanat: syöpätaudit; lihaskunto; lihasmassa; voimaharjoittelu

Vapaat asiasanat: lihaskato; kakeksia

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2022

JUFO-taso: 1