A1 Journal article (refereed)
Identification of Proprioceptive Thalamocortical Tracts in Children : Comparison of fMRI, MEG, and Manual Seeding of Probabilistic Tractography (2022)
Jaatela, J., Aydogan, D. B., Nurmi, T., Vallinoja, J., & Piitulainen, H. (2022). Identification of Proprioceptive Thalamocortical Tracts in Children : Comparison of fMRI, MEG, and Manual Seeding of Probabilistic Tractography. Cerebral Cortex, 32(17), 3736-3751. https://doi.org/10.1093/cercor/bhab444
JYU authors or editors
Publication details
All authors or editors: Jaatela, Julia; Aydogan, Dogu Baran; Nurmi, Timo; Vallinoja, Jaakko; Piitulainen, Harri
Journal or series: Cerebral Cortex
ISSN: 1047-3211
eISSN: 1460-2199
Publication year: 2022
Publication date: 18/01/2022
Volume: 32
Issue number: 17
Pages range: 3736-3751
Publisher: Oxford University Press (OUP)
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1093/cercor/bhab444
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/79818
Abstract
Studying white matter connections with tractography is a promising approach to understand the development of different brain processes, such as proprioception. An emerging method is to use functional brain imaging to select the cortical seed points for tractography, which is considered to improve the functional relevance and validity of the studied connections. However, it is unknown whether different functional seeding methods affect the spatial and microstructural properties of the given white matter connection. Here, we compared functional magnetic resonance imaging, magnetoencephalography, and manual seeding of thalamocortical proprioceptive tracts for finger and ankle joints separately. We showed that all three seeding approaches resulted in robust thalamocortical tracts, even though there were significant differences in localization of the respective proprioceptive seed areas in the sensorimotor cortex, and in the microstructural properties of the obtained tracts. Our study shows that the selected functional or manual seeding approach might cause systematic biases to the studied thalamocortical tracts. This result may indicate that the obtained tracts represent different portions and features of the somatosensory system. Our findings highlight the challenges of studying proprioception in the developing brain and illustrate the need for using multimodal imaging to obtain a comprehensive view of the studied brain process.
Keywords: brain; diagnostics; magnetic resonance imaging; functional magnetic resonance imaging; cerebral cortex; MEG; neurophysiology; imaging; transcranial magnetic stimulation
Free keywords: magnetic resonance imaging; magnetoencephalography; multimodal; passive movement; primary sensorimotor cortex
Contributing organizations
Related projects
- Proprioception in sensorimotor integration in health and disease
- Piitulainen, Harri
- Research Council of Finland
- Proprioception in sensorimotor integration in health and disease (Academy Research Fellow research costs for 2-years in University of Jyväskylä)
- Piitulainen, Harri
- Research Council of Finland
- Competitive funding to strengthen universities’ research profiles. Profiling actions at the JYU, round 3
- Hämäläinen, Keijo
- Research Council of Finland
Ministry reporting: Yes
VIRTA submission year: 2022
JUFO rating: 3