A1 Journal article (refereed)
Identification of Proprioceptive Thalamocortical Tracts in Children : Comparison of fMRI, MEG, and Manual Seeding of Probabilistic Tractography (2022)


Jaatela, J., Aydogan, D. B., Nurmi, T., Vallinoja, J., & Piitulainen, H. (2022). Identification of Proprioceptive Thalamocortical Tracts in Children : Comparison of fMRI, MEG, and Manual Seeding of Probabilistic Tractography. Cerebral Cortex, 32(17), 3736-3751. https://doi.org/10.1093/cercor/bhab444


JYU authors or editors


Publication details

All authors or editorsJaatela, Julia; Aydogan, Dogu Baran; Nurmi, Timo; Vallinoja, Jaakko; Piitulainen, Harri

Journal or seriesCerebral Cortex

ISSN1047-3211

eISSN1460-2199

Publication year2022

Publication date18/01/2022

Volume32

Issue number17

Pages range3736-3751

PublisherOxford University Press (OUP)

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1093/cercor/bhab444

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/79818


Abstract

Studying white matter connections with tractography is a promising approach to understand the development of different brain processes, such as proprioception. An emerging method is to use functional brain imaging to select the cortical seed points for tractography, which is considered to improve the functional relevance and validity of the studied connections. However, it is unknown whether different functional seeding methods affect the spatial and microstructural properties of the given white matter connection. Here, we compared functional magnetic resonance imaging, magnetoencephalography, and manual seeding of thalamocortical proprioceptive tracts for finger and ankle joints separately. We showed that all three seeding approaches resulted in robust thalamocortical tracts, even though there were significant differences in localization of the respective proprioceptive seed areas in the sensorimotor cortex, and in the microstructural properties of the obtained tracts. Our study shows that the selected functional or manual seeding approach might cause systematic biases to the studied thalamocortical tracts. This result may indicate that the obtained tracts represent different portions and features of the somatosensory system. Our findings highlight the challenges of studying proprioception in the developing brain and illustrate the need for using multimodal imaging to obtain a comprehensive view of the studied brain process.


Keywordsbraindiagnosticsmagnetic resonance imagingfunctional magnetic resonance imagingcerebral cortexMEGneurophysiologyimagingtranscranial magnetic stimulation

Free keywordsmagnetic resonance imaging; magnetoencephalography; multimodal; passive movement; primary sensorimotor cortex


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Related projects


Ministry reportingYes

VIRTA submission year2022

JUFO rating3


Last updated on 2024-12-10 at 14:01